S100在口腔黏膜下纤维化中的表达。

Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University Pub Date : 2003-08-01

Xiao-li Xie, Zhan-gui Tang, Zhi-gang Yao

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引用次数: 0

摘要

目的:研究S100在口腔黏膜下纤维化(OSF)中的表达。方法:应用抗S100蛋白单克隆抗体对10例口腔粘膜异常增生(OSF)、10例口腔上皮异常增生(OED)和8例正常口腔上皮进行免疫组化检测。结果:S100在正常口腔黏膜上皮中无表达。OSF和OED病例中有50%的患者出现S100阳性核染色，明显高于正常口腔上皮(P < 0.05)。OSF和OED的阳性染色差异无统计学意义(P > 0.05)。结论:S100的表达与OSF和OED的发展密切相关。OSF和OED的阳性染色表达相同。

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[Expression of S100 in oral submucose fibrosis].

Objective: To study the expression of S100 in oral submucose fibrosis(OSF).

Methods: Immunohistochemistry assay was performed on 10 cases of OSF, 10 cases of oral epithelial dysplasia (OED) and 8 cases of normal oral epithelium using monoclonal antibody against S100 protein.

Results: S100 did not express in the normal oral muscosal epithelium. The S100 positive nuclear staining was found in 50% of the OSF and OED cases, which was significantly higher than that in the normal oral epithelium (P < 0.05). But the positive staining in the OSF and OED cases had no difference (P > 0.05).

Conclusion: S100 expression is closely related to the development of OSF and OED. The positive staining expression in the OSF and OED cases is the same.

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Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University

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