[人类多发性骨髓瘤基因表达谱的变化]。

Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University Pub Date : 2003-06-01

Yi-wu Shi, Wei-xin Hu, Li-jun Tang

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摘要

目的:探讨人多发性骨髓瘤(MM)与正常骨髓基因表达的差异。方法:采用cDNA芯片检测10例未治疗的MM患者和10例正常骨髓的单核细胞mRNA。结果:在2048个基因中，我们发现566个不同的表达基因，其中在MM中表达高于正常骨髓的有237个，低于正常骨髓的有329个。结论:mm的发病机制可能涉及多种基因，cDNA芯片技术是研究肿瘤相关基因的有效工具。

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[Gene expression profile changes in human multiple myeloma].

Objective: To determine the difference in gene expression between human multiple myeloma (MM) and normal bone marrow.

Methods: cDNA chip was used to detect the mRNA of mononuclear cell from 10 untreated MM patients and 10 cases of normal bone marrow.

Results: Of the 2,048 genes, we found 566 different expression genes, of which the expression of 237 genes was higher and 329 lower in MM than in the normal bone marrow.

Conclusion: Many genes may be involved in the pathogenesis of MM. cDNA chip technology is an effective tool in the study of tumor related genes.

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Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University

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