精神分裂症患者烟酸皮肤潮红反应与必需脂肪酸的关系

IF 2.9 4区医学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Prostaglandins, leukotrienes, and essential fatty acids Pub Date : 2003-12-01 DOI:10.1016/j.plefa.2003.08.013

Erik Messamore

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引用次数: 44

摘要

皮肤对烟酸的潮红反应是由皮肤释放血管舒张前列腺素选择性介导的。许多精神分裂症(SCZ)患者对烟酸的正常皮肤潮红反应减弱。这一发现提示SCZ中前列腺素信号异常。由于前列腺素来源于花生四烯酸(AA)，因此皮肤异常潮红反应的发现与生化数据一致，表明相当一部分SCZ患者体内AA和其他必需脂肪酸(EFAs)的相对消耗。本文将描述皮肤对烟酸反应的机制，并将回顾证据表明对烟酸的反应在SCZ中是异常的，这种异常与精神药物无关，它可能是许多SCZ患者中存在的EFA缺乏的标志。

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Relationship between the niacin skin flush response and essential fatty acids in schizophrenia.

The skin flush response to niacin is selectively mediated by the release of vasodilatory prostaglandins from the skin. The normal skin flush response to niacin is attenuated in many individuals with schizophrenia (SCZ). This finding suggests abnormal prostaglandin signaling in SCZ. Since prostaglandins are derived from arachidonic acid (AA), the finding of an abnormal skin flush response is consistent with biochemical data suggesting relative depletion of AA, and other essential fatty acids (EFAs), in a substantial portion of people with SCZ. This paper will describe the mechanism of the skin flush response to niacin, and will review evidence that the response to niacin is abnormal in SCZ, that this abnormality is not related to psychotropic medications, and that it may be a marker of the EFA deficiency which has been documented to be present in many patients with SCZ.

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来源期刊

Prostaglandins, leukotrienes, and essential fatty acids 医学-内分泌学与代谢

CiteScore

6.40

自引率

6.70%

发文量

审稿时长

13.2 weeks

期刊介绍： The role of lipids, including essential fatty acids and their prostaglandin, leukotriene and other derivatives, is now evident in almost all areas of biomedical science. Cell membrane behaviour and cell signalling in all tissues are highly dependent on the lipid constituents of cells. Prostaglandins, Leukotrienes & Essential Fatty Acids aims to cover all aspects of the roles of lipids in cellular, organ and whole organism function, and places a particular emphasis on human studies. Papers concerning all medical specialties are published. Much of the material is particularly relevant to the development of novel treatments for disease.