15-脱氧-delta12,14-前列腺素J2对il- 1诱导的人内皮细胞上皮中性粒细胞活化蛋白-78表达的影响。

IF 3
Tadaatsu Imaizumi , Mika Kumagai , Masaharu Hatakeyama , Wakako Tamo , Koji Yamashita , Hidemi Yoshida , Hirofumi Munakata , Kei Satoh
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引用次数: 0

摘要

上皮中性粒细胞活化肽-78 (ENA-78)是CXC趋化因子的一员。它是由内皮细胞受白细胞介素-1 (IL-1)和其他CXC趋化因子如IL-8和生长相关癌基因蛋白- α (gro - α)的刺激而产生的。内皮细胞il -1诱导的ENA-78的产生可能对中性粒细胞活化的调节很重要。15-Deoxy-Delta(12,14)-前列腺素J(2) (15d-PGJ(2))是过氧化物酶体增殖激活受体γ (ppar - γ)的天然配体,影响多种基因的表达。我们检测了15d-PGJ(2)对il -1 -刺激的内皮细胞中ENA-78表达的影响。15d-PGJ(2)抑制IL-1诱导的ENA-78表达,但不抑制IL-8或gro - α的表达。另一种ppar - γ激动剂西格列酮对ENA-78的表达没有影响,提示15d-PGJ(2)可能以ppar - γ无关的方式抑制ENA-78的表达。15d-PGJ(2)可能通过调节内皮细胞中CXC趋化因子的平衡来调节炎症反应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effect of 15-deoxy-Δ12,14-prostaglandin J2 on IL-1β-induced expression of epithelial neutrophil-activating protein-78 in human endothelial cells
Epithelial neutrophil-activating peptide-78 (ENA-78) is a member of CXC chemokines. It is produced by endothelial cells stimulated with interleukin-1 (IL-1), along with other CXC chemokines such as IL-8 and growth-related oncogene protein-α (GRO-α). IL-1-induced ENA-78 production by endothelial cells may be important for the regulation of neutrophil activation. 15-Deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) is a natural ligand for peroxisome proliferator-activated receptor-γ (PPAR-γ) and affects the expression of various genes. We examined the effect of 15d-PGJ2 on the expression of ENA-78 in cultured endothelial cells stimulated with IL-1β. 15d-PGJ2 inhibited the IL-1β-induced expression of ENA-78, but not the expression of IL-8 or GRO-α in response to IL-1. Ciglitazone, another agonist for PPAR-γ, had no effect on the expression of ENA-78, suggesting that 15d-PGJ2 may inhibit the expression of ENA-78 in a PPAR-γ-independent manner. 15d-PGJ2 may modulate inflammatory reactions by regulating the balance of CXC chemokines in endothelial cells.
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来源期刊
Prostaglandins, leukotrienes, and essential fatty acids
Prostaglandins, leukotrienes, and essential fatty acids Clinical Biochemistry, Endocrinology, Diabetes and Metabolism
CiteScore
5.30
自引率
0.00%
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0
审稿时长
64 days
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