{"title":"磷壁酸的合成。胞苷5′-二磷酸甘油酯浓度的调控","authors":"Luis Glaser","doi":"10.1016/0926-6534(65)90025-4","DOIUrl":null,"url":null,"abstract":"<div><p>The partial purification of a cytidine 5′-diphosphateglycerol pyrophosphatase from <em>Bacillus subtilis</em> (NCTC 3610) is described. The <em>K</em><sub><em>m</em></sub> for cytidine 5′-diphosphateglycerol is 1.6·10<sup>−3</sup><em>M</em>. It is suggested that the function of this enzyme is to prevent the accumulation of cytidine 5′-diphosphateglycerol under conditions where the rate of teichoic acid synthesis is decreased. A similar mechanism is suggested for the control <em>in vivo</em> of the concentration of some other nucleoside diphosphate sugars.</p></div>","PeriodicalId":100163,"journal":{"name":"Biochimica et Biophysica Acta (BBA) - Mucoproteins and Mucopolysaccharides","volume":"101 1","pages":"Pages 6-15"},"PeriodicalIF":0.0000,"publicationDate":"1965-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0926-6534(65)90025-4","citationCount":"19","resultStr":"{\"title\":\"The synthesis of teichoic acid IV. On the regulation of cytidine 5′-diphosphateglycerol concentration\",\"authors\":\"Luis Glaser\",\"doi\":\"10.1016/0926-6534(65)90025-4\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The partial purification of a cytidine 5′-diphosphateglycerol pyrophosphatase from <em>Bacillus subtilis</em> (NCTC 3610) is described. The <em>K</em><sub><em>m</em></sub> for cytidine 5′-diphosphateglycerol is 1.6·10<sup>−3</sup><em>M</em>. It is suggested that the function of this enzyme is to prevent the accumulation of cytidine 5′-diphosphateglycerol under conditions where the rate of teichoic acid synthesis is decreased. A similar mechanism is suggested for the control <em>in vivo</em> of the concentration of some other nucleoside diphosphate sugars.</p></div>\",\"PeriodicalId\":100163,\"journal\":{\"name\":\"Biochimica et Biophysica Acta (BBA) - Mucoproteins and Mucopolysaccharides\",\"volume\":\"101 1\",\"pages\":\"Pages 6-15\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1965-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0926-6534(65)90025-4\",\"citationCount\":\"19\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biochimica et Biophysica Acta (BBA) - Mucoproteins and Mucopolysaccharides\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/0926653465900254\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biochimica et Biophysica Acta (BBA) - Mucoproteins and Mucopolysaccharides","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0926653465900254","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The synthesis of teichoic acid IV. On the regulation of cytidine 5′-diphosphateglycerol concentration
The partial purification of a cytidine 5′-diphosphateglycerol pyrophosphatase from Bacillus subtilis (NCTC 3610) is described. The Km for cytidine 5′-diphosphateglycerol is 1.6·10−3M. It is suggested that the function of this enzyme is to prevent the accumulation of cytidine 5′-diphosphateglycerol under conditions where the rate of teichoic acid synthesis is decreased. A similar mechanism is suggested for the control in vivo of the concentration of some other nucleoside diphosphate sugars.
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