{"title":"不同哺乳动物种类肝素的生物化学和物理比较","authors":"Grant H. Barlow, Lyle J. Coen, Milton M. Mozen","doi":"10.1016/0926-6526(64)90004-7","DOIUrl":null,"url":null,"abstract":"<div><p>Since improvements in the isolation procedure have resulted in heparin of high biological activity, the question of species difference has been reexamined. We have isolated heparin from dog, beef, hog, sheep and human tissue by selective fractionation with quaternary ammonium compounds. Based on our results we would suggest that heparins isolated from various mammalian species are biologically, chemically and physically similar. The biological variations previously observed may well be a result of different degree of purity in the heparin isolated.</p></div>","PeriodicalId":100172,"journal":{"name":"Biochimica et Biophysica Acta (BBA) - Specialized Section on Mucoproteins and Mucopolysaccharides","volume":"83 3","pages":"Pages 272-277"},"PeriodicalIF":0.0000,"publicationDate":"1964-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0926-6526(64)90004-7","citationCount":"30","resultStr":"{\"title\":\"A biological chemical and physical comparison of heparin from differential mammalian species\",\"authors\":\"Grant H. Barlow, Lyle J. Coen, Milton M. Mozen\",\"doi\":\"10.1016/0926-6526(64)90004-7\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Since improvements in the isolation procedure have resulted in heparin of high biological activity, the question of species difference has been reexamined. We have isolated heparin from dog, beef, hog, sheep and human tissue by selective fractionation with quaternary ammonium compounds. Based on our results we would suggest that heparins isolated from various mammalian species are biologically, chemically and physically similar. The biological variations previously observed may well be a result of different degree of purity in the heparin isolated.</p></div>\",\"PeriodicalId\":100172,\"journal\":{\"name\":\"Biochimica et Biophysica Acta (BBA) - Specialized Section on Mucoproteins and Mucopolysaccharides\",\"volume\":\"83 3\",\"pages\":\"Pages 272-277\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1964-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0926-6526(64)90004-7\",\"citationCount\":\"30\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biochimica et Biophysica Acta (BBA) - Specialized Section on Mucoproteins and Mucopolysaccharides\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/0926652664900047\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biochimica et Biophysica Acta (BBA) - Specialized Section on Mucoproteins and Mucopolysaccharides","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0926652664900047","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
A biological chemical and physical comparison of heparin from differential mammalian species
Since improvements in the isolation procedure have resulted in heparin of high biological activity, the question of species difference has been reexamined. We have isolated heparin from dog, beef, hog, sheep and human tissue by selective fractionation with quaternary ammonium compounds. Based on our results we would suggest that heparins isolated from various mammalian species are biologically, chemically and physically similar. The biological variations previously observed may well be a result of different degree of purity in the heparin isolated.
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