糖尿病大鼠脂质代谢酶缺陷的细胞内定位

Biochimica et Biophysica Acta (BBA) - Specialized Section on Lipids and Related Subjects Pub Date : 1964-04-20 DOI:10.1016/0926-6542(64)90073-3

Alfred Gellhorn, William Benjamin

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引用次数: 128

摘要

在未经治疗和胰岛素治疗的糖尿病大鼠和维持无脂饮食的大鼠的脂肪组织和肝脏的匀浆和其他亚细胞组分中，研究了硬脂酸向油酸的转化。单不饱和脂肪酸的合成是一个加氧酶反应，需要分子氧和DPNH或TPNH。反应的位置已经定位在微粒体上。在糖尿病患者中，微粒体酶促将酸酯转化为油酸酯的过程停止。脂质代谢的这种缺陷，与脂质生物合成的整体抑制是分开的，可以通过胰岛素治疗来纠正。

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The intracellular localization of an enzymatic defect of lipid metabolism in diabetic rats

The conversion of stearic acid to oleic acid has been studied in homogenates and other subcellular fractions of adipose tissues and liver of untreated and insulin-treated diabetic rats and rats maintained on a fat-free diet. The synthesis of the monounsaturrated fatty acid is an oxygenase reaction requiring molecular oxygen and DPNH or TPNH. The site of the reaction has been localized to the microsomes.

In diabetes, the microsomal enzymatic conversion of strearate to oleate stops. This defect in lipid metabolism, which is separable from the overall depression of lipid biosynthesis, is corrected by insulin therapy.

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Biochimica et Biophysica Acta (BBA) - Specialized Section on Lipids and Related Subjects

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