Chunjing Guo Ph.D , Min Cao MD , Ningning Diao MD , Wenxin Wang MD , Hongxu Geng MD , Yanguo Su MD , Tianying Sun BD , Xinyue Lu BD , Ming Kong Ph.D , Daquan Chen Ph.D
{"title":"针对糖尿病肾病的天然多糖杂交胶束的新型ph反应性e -选择素","authors":"Chunjing Guo Ph.D , Min Cao MD , Ningning Diao MD , Wenxin Wang MD , Hongxu Geng MD , Yanguo Su MD , Tianying Sun BD , Xinyue Lu BD , Ming Kong Ph.D , Daquan Chen Ph.D","doi":"10.1016/j.nano.2023.102696","DOIUrl":null,"url":null,"abstract":"<div><p><span>Diabetic nephropathy<span><span> (DN) is an important complication of diabetes and is the main cause of end-stage renal disease. The pathogenesis of DN is complex, including glucose and </span>lipid metabolism disorder<span><span><span><span>, inflammation, and so on. Novel hybrid micelles loaded </span>Puerarin<span><span> (Pue) based on Angelica sinensis </span>polysaccharides (ASP) and </span></span>Astragalus polysaccharide (APS) were fabricated with pH-responsive ASP-hydrazone-ibuprofen (BF) materials (ASP-HZ-BF, SHB) and </span>sialic acid (SA) modified APS-hydrazone-ibuprofen materials (SA/APS-HZ-BF, SPHB) by thin-film dispersion method. The SA in hybrid micelles can specifically bind to the </span></span></span><em>E</em><span><span>-selectin receptor which is highly expressed in inflammatory vascular endothelial cells<span>. The loaded Pue could be accurately delivered to the inflammatory site of the kidney in response to the low pH microenvironment. Overall, this study provides a promising strategy for developing hybrid micelles based on natural polysaccharides for the </span></span>treatment of diabetic nephropathy by inhibiting renal inflammatory reactions, and antioxidant stress.</span></p></div>","PeriodicalId":396,"journal":{"name":"Nanomedicine: Nanotechnology, Biology and Medicine","volume":null,"pages":null},"PeriodicalIF":4.7000,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Novel pH-responsive E-selectin targeting natural polysaccharides hybrid micelles for diabetic nephropathy\",\"authors\":\"Chunjing Guo Ph.D , Min Cao MD , Ningning Diao MD , Wenxin Wang MD , Hongxu Geng MD , Yanguo Su MD , Tianying Sun BD , Xinyue Lu BD , Ming Kong Ph.D , Daquan Chen Ph.D\",\"doi\":\"10.1016/j.nano.2023.102696\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p><span>Diabetic nephropathy<span><span> (DN) is an important complication of diabetes and is the main cause of end-stage renal disease. The pathogenesis of DN is complex, including glucose and </span>lipid metabolism disorder<span><span><span><span>, inflammation, and so on. Novel hybrid micelles loaded </span>Puerarin<span><span> (Pue) based on Angelica sinensis </span>polysaccharides (ASP) and </span></span>Astragalus polysaccharide (APS) were fabricated with pH-responsive ASP-hydrazone-ibuprofen (BF) materials (ASP-HZ-BF, SHB) and </span>sialic acid (SA) modified APS-hydrazone-ibuprofen materials (SA/APS-HZ-BF, SPHB) by thin-film dispersion method. The SA in hybrid micelles can specifically bind to the </span></span></span><em>E</em><span><span>-selectin receptor which is highly expressed in inflammatory vascular endothelial cells<span>. The loaded Pue could be accurately delivered to the inflammatory site of the kidney in response to the low pH microenvironment. Overall, this study provides a promising strategy for developing hybrid micelles based on natural polysaccharides for the </span></span>treatment of diabetic nephropathy by inhibiting renal inflammatory reactions, and antioxidant stress.</span></p></div>\",\"PeriodicalId\":396,\"journal\":{\"name\":\"Nanomedicine: Nanotechnology, Biology and Medicine\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.7000,\"publicationDate\":\"2023-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nanomedicine: Nanotechnology, Biology and Medicine\",\"FirstCategoryId\":\"1\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1549963423000473\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"BIOTECHNOLOGY & APPLIED MICROBIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nanomedicine: Nanotechnology, Biology and Medicine","FirstCategoryId":"1","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1549963423000473","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOTECHNOLOGY & APPLIED MICROBIOLOGY","Score":null,"Total":0}
Diabetic nephropathy (DN) is an important complication of diabetes and is the main cause of end-stage renal disease. The pathogenesis of DN is complex, including glucose and lipid metabolism disorder, inflammation, and so on. Novel hybrid micelles loaded Puerarin (Pue) based on Angelica sinensis polysaccharides (ASP) and Astragalus polysaccharide (APS) were fabricated with pH-responsive ASP-hydrazone-ibuprofen (BF) materials (ASP-HZ-BF, SHB) and sialic acid (SA) modified APS-hydrazone-ibuprofen materials (SA/APS-HZ-BF, SPHB) by thin-film dispersion method. The SA in hybrid micelles can specifically bind to the E-selectin receptor which is highly expressed in inflammatory vascular endothelial cells. The loaded Pue could be accurately delivered to the inflammatory site of the kidney in response to the low pH microenvironment. Overall, this study provides a promising strategy for developing hybrid micelles based on natural polysaccharides for the treatment of diabetic nephropathy by inhibiting renal inflammatory reactions, and antioxidant stress.
期刊介绍：
Nanomedicine: Nanotechnology, Biology and Medicine (NBM) is an international, peer-reviewed journal presenting novel, significant, and interdisciplinary theoretical and experimental results related to nanoscience and nanotechnology in the life and health sciences. Content includes basic, translational, and clinical research addressing diagnosis, treatment, monitoring, prediction, and prevention of diseases.
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