R L Stephen, J E Crabtree, T Yoshimura, C L Clayton, M F Dixon, P A Robinson
{"title":"与正常胃组织相比，胃癌中锌指蛋白zFOC1转录本增加。","authors":"R L Stephen, J E Crabtree, T Yoshimura, C L Clayton, M F Dixon, P A Robinson","doi":"10.1136/mp.56.3.167","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Screening of cDNA arrays of the IMAGE library identified human zFOC1 as a differentially expressed cDNA that was upregulated in KATO III gastric cancer cells following stimulation with the gastric pathogen Helicobacter pylori.</p><p><strong>Aims: </strong>To determine the expression of zFOC1 in gastric mucosa with and without H pylori infection and in patients with gastric cancer.</p><p><strong>Results: </strong>zFOC1 is localised on chromosome 12q24.3 and encodes a zinc finger protein. Expression studies in human H pylori infected and uninfected gastric biopsies, gastric tumours, and gastric cancer cell lines revealed that zFOCI gene transcripts are significantly higher in gastric cancer than in non-cancerous gastric tissues.</p><p><strong>Conclusions: </strong>The zFOC1 gene appears to be a tumour marker associated with gastric cancer.</p>","PeriodicalId":79512,"journal":{"name":"Molecular pathology : MP","volume":"56 3","pages":"167-71"},"PeriodicalIF":0.0000,"publicationDate":"2003-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1187313/pdf/mp56000167.pdf","citationCount":"5","resultStr":"{\"title\":\"Increased zinc finger protein zFOC1 transcripts in gastric cancer compared with normal gastric tissue.\",\"authors\":\"R L Stephen, J E Crabtree, T Yoshimura, C L Clayton, M F Dixon, P A Robinson\",\"doi\":\"10.1136/mp.56.3.167\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Screening of cDNA arrays of the IMAGE library identified human zFOC1 as a differentially expressed cDNA that was upregulated in KATO III gastric cancer cells following stimulation with the gastric pathogen Helicobacter pylori.</p><p><strong>Aims: </strong>To determine the expression of zFOC1 in gastric mucosa with and without H pylori infection and in patients with gastric cancer.</p><p><strong>Results: </strong>zFOC1 is localised on chromosome 12q24.3 and encodes a zinc finger protein. Expression studies in human H pylori infected and uninfected gastric biopsies, gastric tumours, and gastric cancer cell lines revealed that zFOCI gene transcripts are significantly higher in gastric cancer than in non-cancerous gastric tissues.</p><p><strong>Conclusions: </strong>The zFOC1 gene appears to be a tumour marker associated with gastric cancer.</p>\",\"PeriodicalId\":79512,\"journal\":{\"name\":\"Molecular pathology : MP\",\"volume\":\"56 3\",\"pages\":\"167-71\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2003-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1187313/pdf/mp56000167.pdf\",\"citationCount\":\"5\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Molecular pathology : MP\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1136/mp.56.3.167\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Molecular pathology : MP","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1136/mp.56.3.167","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Increased zinc finger protein zFOC1 transcripts in gastric cancer compared with normal gastric tissue.
Background: Screening of cDNA arrays of the IMAGE library identified human zFOC1 as a differentially expressed cDNA that was upregulated in KATO III gastric cancer cells following stimulation with the gastric pathogen Helicobacter pylori.
Aims: To determine the expression of zFOC1 in gastric mucosa with and without H pylori infection and in patients with gastric cancer.
Results: zFOC1 is localised on chromosome 12q24.3 and encodes a zinc finger protein. Expression studies in human H pylori infected and uninfected gastric biopsies, gastric tumours, and gastric cancer cell lines revealed that zFOCI gene transcripts are significantly higher in gastric cancer than in non-cancerous gastric tissues.
Conclusions: The zFOC1 gene appears to be a tumour marker associated with gastric cancer.
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