[吸入皮质激素和全身继发性效应:争议]。

Allergie et immunologie Pub Date : 2002-11-01
A Köhler-Pâris, H Peyrière, D Vincent
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引用次数: 0

摘要

文献中大量比较吸入皮质类固醇(CI)对全身影响的研究往往得出相互矛盾的结果。大多数研究报告由于吸入大剂量皮质类固醇而对肾上腺上功能产生继发性生物学效应而无临床效果。对骨骼的继发性影响的监测很难证明。最后,在治疗的第一年,哮喘儿童的识别速度减慢,但成年后的水平不受影响。这些结果的可变性与前者通过一般途径服用皮质类固醇有关。因此,通过全身途径给药皮质类固醇使得仅吸入皮质类固醇的继发性效应难以评估。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Inhaled corticoids and systemic secondary effects: controversies].

Studies that compare the systemic impact of inhaled corticosteroids (CI) abound in the literature often with contradictory results. Most of the studies report secondary biological effects in the suprarenal function without clinical effect due to taking high doses of inhaled corticosteroids. Surveillance of the secondary effects on bone is difficult to demonstrate. Finally, speed for recognition in asthmatic children during the first year of treatment is slowed down but the level at adult age is not affected. The variability of these results is associated with the former taking of corticosteroids by the general route. Administration of corticosteroids by the systemic route, therefore makes difficult the evaluation of secondary effects due only taking inhaled corticosteroids.

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