土耳其冠脉造影确定的冠心病患者的危险因素分布和预防性用药

Kenan Sonmez, Ahmet Akcay, Mustafa Akcakoyun, Durmus Demir, Orhan Hakan Elonu, Selcuk Pala, Nilüfer Eksi Duran, Murat Gencbay, Muzaffer Degertekin, Fikret Turan
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引用次数: 9

摘要

背景:冠状动脉疾病(CAD)是我国成人死亡的主要原因。在临床实践中,对冠心病进行充分的二级预防首先需要充分认识到危险因素的分布。我们研究的目的是确定我们中心经血管造影证实的冠心病患者冠状动脉危险因素的患病率和预防性药物的使用情况,并将其与EUROASPIRE I和II研究的结果进行比较。设计:横断面观察性研究。方法:我们的患者包括617名受试者(516名男性,平均年龄57.2±10.8岁),他们在2000年1月至2000年5月期间首次接受了血管造影,并发现了明显的冠状动脉病变。血管造影前记录年龄、性别、早发冠心病(FH)家族史、糖尿病(DM)、高血压(HT)家族史、血脂、吸烟、体重指数、腰围、臀围、体力活动等资料。对这些病例出院时接受的治疗进行了调查。将获得的数据与EUROASPIRE I和II试验的结果进行比较,EUROASPIRE研究了欧洲国家CAD患者中现有危险因素和预防性用药的频率。结果:高脂血症、FH、DM、HT、吸烟、肥胖、中心性肥胖分别占52%、26%、20%、41%、65%、18%和29%。抗血小板、受体阻滞剂、ACE抑制剂、他汀类药物和钙拮抗剂的使用率分别为99%、86%、40%、63%和16%。结论:通过危险因素的比较,我们的研究对象中肥胖和糖尿病的患病率与9个欧洲国家的平均水平相似。在我们的研究对象中,吸烟的比例相当高,而高血压、高脂血症和早发冠心病家族史的比例低于欧洲平均水平。在我们的病例中,出院时预防性用药的频率高于欧洲平均水平。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Distribution of risk factors and prophylactic drug usage in Turkish patients with angiographically established coronary artery disease.

Background: Coronary artery disease (CAD) is the leading cause of adult deaths in our country. In clinical practice, an adequate level of secondary prevention towards CAD primarily requires full recognition of the distribution of risk factors. The aim of our study was to determine the prevalence of coronary risk factors and the use of prophylactic drugs among patients who have an angiographically proven CAD in our centre, and to compare it with those of the EUROASPIRE I and II studies.

Design: Cross-sectional, observational study.

Methods: Our patients comprise 617 subjects (516 male, mean age 57.2 +/- 10.8 years) who underwent an angiography between January 2000 and May 2000 for the first time and in whom significant coronary lesions were detected. Age, gender, family history of premature CAD (FH), diabetes mellitus (DM), hypertension (HT), lipid profile, smoking, body mass index, waist circumference, hip circumference and physical activity data were recorded prior to angiography. The medical treatments received by these cases at discharge from hospital were investigated. Data thus obtained were compared with the results of the EUROASPIRE I and II trials, which studied the frequency of existing risk factors and prophylactic drug use among CAD patients in European countries.

Results: Hyperlipidaemia, FH, DM, HT, smoking, obesity, central obesity were found in 52, 26, 20, 41, 65, 18 and 29% of patients, respectively. The use of antiplatelets, beta-blockers, ACE inhibitors, statins and calcium antagonists were 99, 86, 40, 63 and 16%, respectively.

Conclusion: Upon comparison of the risk factors, prevalence of obesity and DM was found to be similar to the average of nine European countries among our subjects. Smoking was found to be considerably higher, whereas HT, hyperlipidaemia and family history of premature CAD were lower than the European average within our subjects. In our cases the frequency of prophylactic drug usage at discharge was higher than the European means.

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