{"title":"猫胃底NANC松弛的氮能和肽能成分。","authors":"L Chernaeva","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>The mediators of non-adrenergic non-cholinergic (NANC) relaxation of cat gastric fundus were examined in vitro. Electrical field stimulation (EFS, 10 pulses train and 10 s train) induced tetrodotoxin (TTX) sensitive relaxations in the presence of atropine and guanethidine. Relaxation induced by vasoactive intestinal polypeptide (VIP) was abolished by alpha-chymotrypsin (alpha-CT). N omega-nitro-L-arginine (L-NNA) completely inhibited relaxation induced by EFS of 10 pulses train at all frequencies. L-NNA completely inhibited the relaxation induced by EFS of 10 s train at low frequencies but partly that at high frequencies; alpha-CT had an additive to L-NNA inhibitory effect on the relaxation. The results suggest a nitrergic nature of NANC relaxation in cat gastric fundus upon EFS of 10 pulses, and a nitrergic and peptidergic (VIP) nature of relaxations upon EFS of 10 s train.</p>","PeriodicalId":7035,"journal":{"name":"Acta physiologica et pharmacologica Bulgarica","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Nitrergic and peptidergic components of NANC relaxations of cat gastric fundus.\",\"authors\":\"L Chernaeva\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The mediators of non-adrenergic non-cholinergic (NANC) relaxation of cat gastric fundus were examined in vitro. Electrical field stimulation (EFS, 10 pulses train and 10 s train) induced tetrodotoxin (TTX) sensitive relaxations in the presence of atropine and guanethidine. Relaxation induced by vasoactive intestinal polypeptide (VIP) was abolished by alpha-chymotrypsin (alpha-CT). N omega-nitro-L-arginine (L-NNA) completely inhibited relaxation induced by EFS of 10 pulses train at all frequencies. L-NNA completely inhibited the relaxation induced by EFS of 10 s train at low frequencies but partly that at high frequencies; alpha-CT had an additive to L-NNA inhibitory effect on the relaxation. The results suggest a nitrergic nature of NANC relaxation in cat gastric fundus upon EFS of 10 pulses, and a nitrergic and peptidergic (VIP) nature of relaxations upon EFS of 10 s train.</p>\",\"PeriodicalId\":7035,\"journal\":{\"name\":\"Acta physiologica et pharmacologica Bulgarica\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2000-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Acta physiologica et pharmacologica Bulgarica\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta physiologica et pharmacologica Bulgarica","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Nitrergic and peptidergic components of NANC relaxations of cat gastric fundus.
The mediators of non-adrenergic non-cholinergic (NANC) relaxation of cat gastric fundus were examined in vitro. Electrical field stimulation (EFS, 10 pulses train and 10 s train) induced tetrodotoxin (TTX) sensitive relaxations in the presence of atropine and guanethidine. Relaxation induced by vasoactive intestinal polypeptide (VIP) was abolished by alpha-chymotrypsin (alpha-CT). N omega-nitro-L-arginine (L-NNA) completely inhibited relaxation induced by EFS of 10 pulses train at all frequencies. L-NNA completely inhibited the relaxation induced by EFS of 10 s train at low frequencies but partly that at high frequencies; alpha-CT had an additive to L-NNA inhibitory effect on the relaxation. The results suggest a nitrergic nature of NANC relaxation in cat gastric fundus upon EFS of 10 pulses, and a nitrergic and peptidergic (VIP) nature of relaxations upon EFS of 10 s train.
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