CPAP对健康受试者在甲胆碱诱导支气管收缩时呼吸困难感知的影响。

S Kostianev, G Liistro, C Veriter, D Stanescu
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引用次数: 0

摘要

在哮喘患者中应用持续气道正压通气(CPAP)可减少呼吸困难(B)。在健康受试者中研究了CPAP对诱导支气管收缩的影响。B的变化与肺功能指标的变化有关。9例20 ~ 27岁男性健康志愿者,吸入1 ~ 128 mg/ml甲胆碱(M)致急性支气管收缩,CPAP (0.5 kPa) 1 min,然后吸入沙丁胺醇。采用肺活量测定法测定1 s内用力呼气量(FEV1)和肺活量(VC),呼气末肺活量(EELL)通过诱导容积描记法得出吸气量(IC)。B采用Borg量表评定。最大M浓度处理后,FEV1较对照组下降14% (p < 0.01), Borg评分(BS)升高至2.4 (p < 0.01)。在9名受试者中,有7名我们发现FEV1和BS的变化有显著的相关性(p < 0.05)。CPAP治疗时BS降低(p < 0.01),沙丁胺醇治疗后BS进一步显著降低。支气管收缩时IC和FEV1的变化以及CPAP时IC和BS的变化之间没有相关性。综上所述,在健康的支气管收缩受试者中,CPAP可显著降低BS,吸入沙丁胺醇可进一步改善BS。B与FEV1的变化有关,而与IC无关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effect of CPAP on breathlessness perception in healthy subjects during methacholine induced bronchoconstriction.

Application of continuous positive airway pressure (CPAP) in asthmatic patients decreases breathlessness (B). The effect of CPAP on induced bronchoconstriction was studied in healthy subjects. The changes in B were related to changes in lung function indices. In nine healthy volunteers, males aged 20-27 years, acute bronchoconstriction was induced by inhalation of 1 to 128 mg/ml methacholine (M). CPAP (0.5 kPa) was then applied for 1 min. It was followed by inhalation of albuterol. Forced expiratory volume in 1 s (FEV1) and vital capacity (VC) were measured by spirometry and end expiratory lung level (EELL), to derive inspiratory capacity (IC), by inductive plethysmography. B was assessed by Borg scale. After the maximal concentration of M, FEV1 decreased by 14% (p < 0.01) as compared to the control values and Borg score (BS) increased to 2.4 (p < 0.01). In 7 out of 9 subjects we found a significant (p < 0.05) correlation between the changes in FEV1 and BS. BS decreased during CPAP (p < 0.01) and it further decreased significantly after albuterol. There was no correlation between the changes in IC and FEV1 during bronchoconstriction, or between IC and BS during CPAP. In conclusion, in healthy subjects with induced bronchoconstriction CPAP decreased significantly BS, which was further improved by inhalation of albuterol. B was related to changes in FEV1 but not in IC.

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