I型干扰素和辅助T细胞的发育

Immunology today Pub Date : 2000-10-01 DOI:10.1016/S0167-5699(00)01710-2

J.David Farrar, Kenneth M Murphy

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引用次数: 112

摘要

I型干扰素(ifn -1)在人类CD4+ T细胞中激活Stat4并促进Th1的发育，但在小鼠中没有。最近，ifn -1诱导的Stat4在人类细胞中的激活被发现需要Stat4和Stat2的相互作用。小鼠和人类之间显著的基因差异解释了人类(而非小鼠)CD4+ T细胞经历ifn -1诱导的Stat4激活和Th1发育的能力。

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Type I interferons and T helper development

Type I interferons (IFN-1s) activate Stat4 and promote Th1 development in human, but not mouse, CD4⁺ T cells. Recently, IFN-1-induced Stat4 activation in human cells was found to require interactions of Stat4 with Stat2. A remarkable genetic dissimilarity between murine and human Stat2 explains the ability of human, but not mouse, CD4⁺ T cells to undergo IFN-1-induced Stat4 activation and Th1 development.

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来源期刊

Immunology today

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