超快速阿片类药物戒毒与30天住院戒毒方案的比较——回顾性随访研究

Eli Lawental
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引用次数: 34

摘要

目的。超快速解毒(URD)作为一种有希望的治疗阿片成瘾的方法最近得到了媒体的广泛关注。URD联合后续纳曲酮被描述为快速和无痛的初始解毒,以及对成瘾的长期治疗。随着URD的治疗开始,文章开始出现在科学文献中。物质成瘾治疗界对URD持怀疑态度,这种怀疑最初是基于对成瘾的理论理解,认为成瘾是一种生物心理社会问题,并且认为仅靠解毒和药物治疗无法提供长期戒断。这种最初的反应后来得到了一些科学研究的支持。URD继续引起争议,导致了这项研究。方法。我们利用现有数据进行了一项URD的试点研究,将其与以色列用于实现长期戒断的传统30天住院戒毒计划(IDP)进行比较。在1996年3月至9月期间,在IDP (N=87)或URD (N=139)进行戒毒的226名18岁或以上的男性和女性样本都接受了这些项目中的治疗。81名(92%)IDP受试者和82名(60%)URD受试者在参加这些项目12至18个月后成功地通过电话采访。结果。结果提供了初步证据,表明URD可能比传统治疗效果差得多,而且费用更高。虽然采用随机分配的前瞻性研究可能更成功地确定这一群体,但没有特定的客户亚组从URD中受益更多。的影响。这项研究似乎为目前长期的阿片类药物成瘾的生物心理社会治疗方案提供了理由。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Ultra Rapid Opiate Detoxification as Compared to 30-Day Inpatient Detoxification Program—A Retrospective Follow-up Study

Purpose. Ultra rapid detoxification (URD) has recently gained significant media attention as a promising treatment for opiate addiction. URD combined with follow-up naltrexone was portrayed as a quick and painless initial detoxification, as well as a long-term cure for the addiction. Following the therapeutic initiation of URD, articles began to emerge in the scientific literature. URD was skeptically viewed by the substance addiction treatment community, skepticism initially based on the theoretical understanding of addiction as a bio-psycho-social problem and the belief that detoxification and medication alone cannot provide long-term abstinence. This initial response was later supported by some scientific studies. URD continues to stir controversy, leading to this study. Methods. We used available data to conduct a pilot study of URD, comparing it to traditional 30-day inpatient detoxification programs (IDP) used in Israel in achieving long-term abstinence. A sample of 226 men and women, 18 years or older, who entered detoxification in the IDP (N=87) or in the URD (N=139) were all clients who received treatment in either of these programs between March and September 1996. Eighty-one (92%) of the IDP subjects and eighty-two (60%) of the URD subjects were successfully interviewed by telephone 12 to 18 months after their participation in these programs. Results. The results provide preliminary evidence that URD may be much less effective and more expensive than traditional treatment. No specific subgroup of clients benefited more from URD, although a prospective study employing random assignment might be more successful in identifying such a group. Implications. This study appears to offer justification for the current longer-term bio-psycho-social treatment alternatives for opiate addiction.

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