{"title":"舍曲林抑制大鼠离体输精管对去甲肾上腺素、KCI和电场刺激的收缩反应","authors":"N. I. Kalyoncu, R. Ozyavuz, S. Karaoglu","doi":"10.1111/j.1365-2680.1999.tb00010.x","DOIUrl":null,"url":null,"abstract":"<div>\n \n <p><b>1</b> The aim of this study was to investigate the effect of sertraline, a selective serotonin re-uptake inhibitor, on contractile responses to noradrenaline (NA), KCI, serotonin (5-HT) and electrical field stimulation of rat isolated vas deferens.</p>\n <p><b>2</b> Pre-treatment with 10<sup>-4</sup> M sertraline showed inhibitory effects on responses to NA, KCI, 5-HT and electrical field stimulation, while pre-treatment with 10 <sup>-6</sup> and 10<sup>-5</sup> M sertraline caused potentiation of responses to NA (10<sup>-7</sup> and 10<sup>-6</sup> M).</p>\n <p><b>3</b> A voltage-dependent calcium channel activator, Bay K 8644, restored the inhibited responses when sertraline was washed out of the organ bath, although restoration could not be seen when sertraline was not removed.</p>\n <p><b>4</b> The inhibition of the contractile responses by sertraline pre-treatment may be via a mechanism through calcium channels which is additional to the selective serotonin re-uptake inhibitory effect of sertraline.</p>\n </div>","PeriodicalId":100151,"journal":{"name":"Autonomic and Autacoid Pharmacology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2009-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1365-2680.1999.tb00010.x","citationCount":"28","resultStr":"{\"title\":\"Sertraline inhibits the contractile responses to noradrenaline, KCI and electrical field stimulation of rat isolated vas deferens\",\"authors\":\"N. I. Kalyoncu, R. Ozyavuz, S. Karaoglu\",\"doi\":\"10.1111/j.1365-2680.1999.tb00010.x\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n <p><b>1</b> The aim of this study was to investigate the effect of sertraline, a selective serotonin re-uptake inhibitor, on contractile responses to noradrenaline (NA), KCI, serotonin (5-HT) and electrical field stimulation of rat isolated vas deferens.</p>\\n <p><b>2</b> Pre-treatment with 10<sup>-4</sup> M sertraline showed inhibitory effects on responses to NA, KCI, 5-HT and electrical field stimulation, while pre-treatment with 10 <sup>-6</sup> and 10<sup>-5</sup> M sertraline caused potentiation of responses to NA (10<sup>-7</sup> and 10<sup>-6</sup> M).</p>\\n <p><b>3</b> A voltage-dependent calcium channel activator, Bay K 8644, restored the inhibited responses when sertraline was washed out of the organ bath, although restoration could not be seen when sertraline was not removed.</p>\\n <p><b>4</b> The inhibition of the contractile responses by sertraline pre-treatment may be via a mechanism through calcium channels which is additional to the selective serotonin re-uptake inhibitory effect of sertraline.</p>\\n </div>\",\"PeriodicalId\":100151,\"journal\":{\"name\":\"Autonomic and Autacoid Pharmacology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2009-01-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1111/j.1365-2680.1999.tb00010.x\",\"citationCount\":\"28\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Autonomic and Autacoid Pharmacology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1111/j.1365-2680.1999.tb00010.x\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Autonomic and Autacoid Pharmacology","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/j.1365-2680.1999.tb00010.x","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 28
摘要
本研究的目的是研究舍曲林(一种选择性5-羟色胺再摄取抑制剂)对大鼠离体输精管对去甲肾上腺素(NA)、KCI、5-羟色胺(5-HT)和电场刺激的收缩反应的影响。2、10-4 M舍曲林预处理对NA、KCI、5-HT和电场刺激的反应有抑制作用，10-6 M和10-5 M舍曲林预处理对NA(10-7和10-6 M)的反应有增强作用。3、电压依赖性钙通道激活剂Bay K 8644在舍曲林被洗出器官浴时恢复了被抑制的反应，但在不去除舍曲林时没有恢复。4舍曲林预处理对收缩反应的抑制可能是通过钙通道的机制，这是舍曲林选择性5 -羟色胺再摄取抑制作用的补充。
Sertraline inhibits the contractile responses to noradrenaline, KCI and electrical field stimulation of rat isolated vas deferens
1 The aim of this study was to investigate the effect of sertraline, a selective serotonin re-uptake inhibitor, on contractile responses to noradrenaline (NA), KCI, serotonin (5-HT) and electrical field stimulation of rat isolated vas deferens.
2 Pre-treatment with 10-4 M sertraline showed inhibitory effects on responses to NA, KCI, 5-HT and electrical field stimulation, while pre-treatment with 10 -6 and 10-5 M sertraline caused potentiation of responses to NA (10-7 and 10-6 M).
3 A voltage-dependent calcium channel activator, Bay K 8644, restored the inhibited responses when sertraline was washed out of the organ bath, although restoration could not be seen when sertraline was not removed.
4 The inhibition of the contractile responses by sertraline pre-treatment may be via a mechanism through calcium channels which is additional to the selective serotonin re-uptake inhibitory effect of sertraline.
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