Antonio Alcami PhD (Wellcome Trust Senior Research Fellow) , Ulrich H. Koszinowski PhD MD (Professor and Chairman)
{"title":"免疫逃避的病毒机制","authors":"Antonio Alcami PhD (Wellcome Trust Senior Research Fellow) , Ulrich H. Koszinowski PhD MD (Professor and Chairman)","doi":"10.1016/S1357-4310(00)01775-5","DOIUrl":null,"url":null,"abstract":"<div><p>During the millions of years they have coexisted with their hosts, viruses have learned how to manipulate host immune control mechanisms. Viral gene functions provide an overview of many relevant principles in cell biology and immunology. Our knowledge of viral gene functions must be integrated into virus–host interaction networks to understand viral pathogenesis, and could lead to new anti-viral strategies and the ability to exploit viral functions as tools in medicine.</p></div>","PeriodicalId":79448,"journal":{"name":"Molecular medicine today","volume":"6 9","pages":"Pages 365-372"},"PeriodicalIF":0.0000,"publicationDate":"2000-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1357-4310(00)01775-5","citationCount":"283","resultStr":"{\"title\":\"Viral mechanisms of immune evasion\",\"authors\":\"Antonio Alcami PhD (Wellcome Trust Senior Research Fellow) , Ulrich H. Koszinowski PhD MD (Professor and Chairman)\",\"doi\":\"10.1016/S1357-4310(00)01775-5\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>During the millions of years they have coexisted with their hosts, viruses have learned how to manipulate host immune control mechanisms. Viral gene functions provide an overview of many relevant principles in cell biology and immunology. Our knowledge of viral gene functions must be integrated into virus–host interaction networks to understand viral pathogenesis, and could lead to new anti-viral strategies and the ability to exploit viral functions as tools in medicine.</p></div>\",\"PeriodicalId\":79448,\"journal\":{\"name\":\"Molecular medicine today\",\"volume\":\"6 9\",\"pages\":\"Pages 365-372\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2000-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/S1357-4310(00)01775-5\",\"citationCount\":\"283\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Molecular medicine today\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1357431000017755\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Molecular medicine today","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1357431000017755","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
During the millions of years they have coexisted with their hosts, viruses have learned how to manipulate host immune control mechanisms. Viral gene functions provide an overview of many relevant principles in cell biology and immunology. Our knowledge of viral gene functions must be integrated into virus–host interaction networks to understand viral pathogenesis, and could lead to new anti-viral strategies and the ability to exploit viral functions as tools in medicine.