dl-3-正丁苯酞改善大鼠实验性蛛网膜下腔出血后脑区域血流量。

Z Z Chong, Y P Feng
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引用次数: 0

摘要

目的:探讨dl-3-正丁基酞(dl-NBP)对实验性大鼠蛛网膜下腔出血(SAH)的影响。方法:侧脑室注入自体动脉血0.35 mL诱导SAH。用氢清除率法测定尾状核区域脑血流(rCBF)。结果:脑出血后15 min,尾状核rCBF迅速显著下降,180 min内rCBF维持在较低水平(约为脑出血前值的50%)。在SAH发病后30-180分钟,kg-1(例如)增加rCBF,但对平均动脉血压没有显著影响。dl-NBP 100毫克。kg-1使SAH后15分钟尾状核rCBF增加26%,180分钟尾状核rCBF增加36%。d-NBP,但不含l-NBP(10毫克)。kg-1, i.p.)增加rCBF。结论:dl-NBP可改善SAH大鼠尾状核rCBF。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
dl-3-n-butylphthalide improves regional cerebral blood flow after experimental subarachnoid hemorrhage in rats.

Aim: To investigate the effect of dl-3-n-butylphthalide (dl-NBP) on experimental subarachnoid hemorrhage (SAH) in rats.

Methods: SAH was induced by injection of autologous artery blood 0.35 mL into lateral ventricle. Regional cerebral blood flow (rCBF) in caudate nucleus was determined by hydrogen clearance method.

Results: A rapid and marked decrease in rCBF in caudate nucleus was observed 15 min after SAH and the rCBF remained at low level (about 50% pre-SAH value) within 180 min. dl-NBP (50, 100 mg.kg-1, i.g.) increased rCBF 30-180 min after the onset of SAH without significant effect on mean artery blood pressure. dl-NBP 100 mg.kg-1 increased rCBF in caudate nucleus by 26% at 15 min and by 36% at 180 min respectively after SAH. d-NBP but not l-NBP (10 mg.kg-1, i.p.) increased rCBF.

Conclusion: dl-NBP improves rCBF in caudate nucleus of rats subjected to SAH.

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