多项临床试验荟萃分析中的复发事件。

Y Wang, M Flather, S Yusuf, Y H Wang, L X Li, Z C Wang
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引用次数: 0

摘要

目的:通过多临床试验的荟萃分析,研究复发事件的药物或治疗的有效性和安全性。方法:提出了一种非参数方法来估计试验荟萃分析的复发事件率。该方法用于血管紧张素转换酶(ACE)抑制剂临床试验的荟萃分析,分别分析ACE抑制剂治疗组和安慰剂治疗组因CHF住院、因CHF或心源性死亡住院和因CHF或任何死亡住院的相对率和超额率。结果:三个终点的估计值分别为69%、74%和76% (P < 0.01)。与安慰剂相比,ACE抑制剂每1000人年减少30例瑞士法郎住院,或每1000人年减少40例心脏死亡或瑞士法郎住院(P < 0.01)。结论:该方法是一种简便、有效的临床试验复发事件荟萃分析方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Recurrent events in meta-analysis of multiple clinical trials.

Aim: To study the efficacy and safety of drug or therapy with recurrent events in meta-analysis of multiple clinical trials.

Methods: A nonparametric approach is proposed to estimate the rates of recurrent events for meta-analysis of trials. The method was used in meta-analysis of angiotensin-converting enzyme (ACE) inhibitor clinical trials to analyze the relative rates and the excess rates between ACE inhibitor and placebo treatment groups for endpoints of hospitalizations for CHF, hospitalizations for CHF or cardiac death, and hospitalizations for CHF or any death, respectively.

Results: The estimates of those three endpoints were 69%, 74%, and 76% (P < 0.01). Compared with placebo, ACE inhibitor reduced 30 cases of hospitalizations for CHF per 1000 person-years, or 40 cardiac deaths or hospitalizations for CHF per 1000 person-years (P < 0.01).

Conclusion: The method was a simple and efficient approach to conduct meta-analysis of clinical trials with recurrent events.

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