5-脂氧合酶的生物学:功能、结构和调控机制。

E S Silverman, J M Drazen
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引用次数: 46

摘要

5-脂氧合酶(5-LO)催化花生四烯酸两步转化为白三烯A4 (LTA4)。第一步是花生四烯酸氧化生成不稳定的中间体5-氢过氧二十碳四烯酸(5-HPETE),第二步是5-HPETE脱水生成LTA4。这些事件是导致所有白三烯合成的第一个承诺反应,并在控制白三烯的生产中起关键作用。5-LO已经进化出许多复杂的结构特征和调节机制,使其能够发挥这种高度专业化的作用。本文对5-LO的生物学研究进行了综述,重点介绍了5-LO的酶功能、蛋白质和基因结构、必需的辅助因子以及控制其表达的多种调控机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The biology of 5-lipoxygenase: function, structure, and regulatory mechanisms.

5-Lipoxygenase (5-LO) catalyzes the two-step conversion of arachidonic acid to leukotriene A4 (LTA4). The first step consists of the oxidation of arachidonic acid to the unstable intermediate 5-hydroperoxyeicosatetraenoic acid (5-HPETE), and the second step is the dehydration of 5-HPETE to form LTA4. These events are the first committed reactions leading to the synthesis of all leukotrienes and play a critical role in controlling leukotriene production. 5-LO has evolved many complex structural features and regulatory mechanisms to allow it to fulfill this highly specialized role. The biology of 5-LO is reviewed here with an emphasis on enzymatic function, protein and gene structure, essential cofactors, and the many regulatory mechanisms controlling its expression.

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