缺氧预处理小鼠脑内超氧化物歧化酶、谷胱甘肽周期氧化酶及脂质过氧化物的变化。

C Duan, F Yan, X Song, G W Lu
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引用次数: 34

摘要

我们建立了一个缺氧预处理的动物模型,并假设氧自由基及其内源性清除酶可能在预处理中起重要作用。为了验证这一假设,在预处理过程中测定了超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)的活性和脂质过氧化物(LPO)的含量。与未预处理的对照动物相比,仅缺氧一次的动物全脑SOD和GSH-Px活性显著降低,海马中LPO含量显著升高。然而,暴露于4次缺氧的动物倾向于恢复到控制水平,低于暴露于1次和2次缺氧的动物。我们的研究结果表明,氧自由基及其特定的清除酶似乎参与了对缺氧耐受的发展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Changes of superoxide dismutase, glutathione perioxidase and lipid peroxides in the brain of mice preconditioned by hypoxia.

We have developed an animal model of hypoxic preconditioning and assumed that oxygen radicals and their endogenous scavenging enzymes may play an important role in the preconditioning. To test this hypothesis, activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and the content of lipid peroxides (LPO) were measured during the preconditioning. Compared with unpreconditioned control animals, in animals exposed to hypoxia only once, the activities of SOD and GSH-Px in whole brain were found to be significantly decreased while the LPO content in the hippocampus significantly increased. However, those in animals exposed to 4 runs of hypoxia tended to return to control levels and were lower than those in animals exposed to 1 and 2 runs of hypoxia. Our results indicate that the oxygen radicals and their specific scavenging enzymes seem to be involved in the development of tolerance to hypoxia.

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