多巴胺D1受体介导双氢乙托啡诱导的大鼠位置偏好。

Zhongguo yao li xue bao = Acta pharmacologica Sinica Pub Date : 1999-04-01

Z H Liu, K G Zhang

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引用次数: 0

摘要

目的:研究多巴胺(DA)受体拮抗剂对二氢埃托啡(DHE)奖赏性的影响。方法:采用条件位置偏好(CPP)范式表征DHE的奖励效应。DA受体拮抗剂皮下或腹腔注射，微注射到伏隔核(NAcc)。结果:DHE(0.05、0.5、5.0 μ g);kg-1, s.c)产生地方偏好(P < 0.01)。DA受体拮抗剂氟哌啶醇和选择性D1受体拮抗剂Sch-23390均能减弱DHE产生的位置偏好(0.5微克)。公斤,南卡罗来纳州)。选择性D2受体拮抗剂l-舒必利和spiperone没有这种作用。结论:NAcc中D1受体(而非D2受体)在DHE的奖赏作用中起重要作用。

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Dihydroetorphine-induced place preference was mediated by dopamine D1 receptors in rats.

Aim: To study the influence of dopamine (DA) receptor antagonists upon the rewarding property of dihydroetorphine (DHE).

Methods: Conditioned place preference (CPP) paradigm was used to characterize the rewarding effect of DHE. DA receptor antagonists were injected administered subcutaneously or peritoneally and microinjected into nucleus accumbens (NAcc).

Results: DHE (0.05, 0.5, and 5.0 micrograms.kg-1, s.c.) produced place preference (P < 0.01). Both the DA receptor antagonist haloperidol and the selective D1 receptor antagonist Sch-23390 attenuated the place preference produced by DHE (0.5 microgram.kg-1, s.c.). l-Sulpiride and spiperone, selective D2 receptor antagonists, had no such effects.

Conclusion: The D1 (but not D2) receptors in NAcc are crucial in the mediation of the rewarding effect of DHE.

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Zhongguo yao li xue bao = Acta pharmacologica Sinica

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