Improving source reconstructions by combining bioelectric and biomagnetic data

Objectives: A framework for combining bioelectric and biomagnetic data is presented. The data are transformed to signal-to-noise ratios and reconstruction algorithms utilizing a new regularization approach are introduced.

Methods: Extensive simulations are carried out for 19 different EEG and MEG montages with radial and tangential test dipoles at different eccentricities and noise levels. The methods are verified by real SEP/SEF measurements. A common realistic volume conductor is used and the less-well-known in-vivo conductivities are matched by calibration to the magnetic data. Single equivalent dipole fits as well as spatiotemporal source models are presented for single and combined modality evaluations and overlaid to anatomic MR images.

Results: Normalized sensitivity and dipole resolution profiles of these acquisition systems are derived from these synthetic data. The methods are verified by simultaneously measured somasensory data.

Conclusions: Superior spatial resolution of the combined data studies is revealed, which is due to the complementary nature of both modalities and the increased number of sensors. a better understanding of the underlying neironal processes can be acheived, since an improved differentiation between quasi-tangential and quasi-radial sources is possible.