自发性高血压大鼠胚胎下丘脑前叶组织移植至正常血压Wistar大鼠对收缩压和心率昼夜节律的影响。

A G Stoynev, P D Penev, O C Ikonomov, K G Usunoff
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引用次数: 0

摘要

下丘脑前部(AH)参与动脉压的调节。AH的视交叉上核(SCN)是产生和/或携带昼夜节律所必需的主要昼夜振荡器。研究了自发性高血压大鼠(SHR)和正常血压Wistar大鼠(NWI)的收缩压(SAP)和心率(HR)的昼夜节律。NWI和SHR的SAP和HR都有明显的昼夜节律,并在黑暗中出现顶相。在移植SHR获得的AH胚胎组织的正常血压大鼠中,SAP的MESOR(节律中线估计统计量)升高,SAP的昼夜节律消失。这一结果表明,移植组织中含有SCN与宿主SCN之间存在相互作用。我们的数据归因于SCN在动脉压昼夜节律的干扰中的作用。尽管观察到HR的振幅降低和相位延迟,但SCN移植物并没有消除HR的昼夜节律。由此可见,大鼠的HR昼夜节律可能并不完全依赖于SCN。大鼠SAP和HR的昼夜节律受到移植物的不同影响,表明大鼠的昼夜节律调节存在多振荡系统。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effect of transplantation of embryonic anterior hypothalamic tissue from spontaneously hypertensive rats to normotensive Wistar rats on circadian rhythms of systolic arterial pressure and heart rate.

The anterior hypothalamus (AH) participates in the regulation of arterial pressure. The suprachiasmatic nuclei (SCN) of the AH are a major circadian oscillator necessary for the generation and/or the entrainment of circadian rhythms. Circadian rhythms of systolic arterial pressure (SAP) and heart rate (HR) were investigated in spontaneously hypertensive rats (SHR) and in normotensive Wistar rats (NWI) with intact SCN, grafted with SHR embryonic AH tissue containing the SCN. Prominent circadian rhythms for SAP and HR in both NWI and SHR with acrophases during dark were found. The elevation of the MESOR (midline-estimated statistic of rhythm) of the SAP in normotensive rats grafted with AH embryonic tissue obtained from SHR was accompanied by disappearance of the circadian rhythm of SAP. This result suggests an interaction between the grafted tissue containing the SCN on the one hand, and the host SCN on the other hand. Our data ascribe a role for the SCN in the entrainment of the circadian rhythm of arterial pressure. The circadian rhythm of HR was not eliminated by the SCN graft in spite of the amplitude decrease and the phase delay observed. It seems that the entrainment of the circadian rhythm of HR is probably not crucially dependent on the SCN in rats. The circadian rhythms of SAP and HR in rats were differently affected by the grafts, thus suggesting a multioscillatory system for circadian regulation in rats.

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