{"title":"G蛋白和Na+/H+交换。","authors":"T A Voyno-Yasenetskaya","doi":"10.1159/000014537","DOIUrl":null,"url":null,"abstract":"<p><p>The Na+/H+ exchangers are important regulators of intracellular pH, cell volume, and cell proliferation. They exist in all cells with a cell-specific pattern of isoform expression. Na+/H+ exchangers are regulated by a variety of extracellular stimuli which activate G-protein-coupled receptors and receptor tyrosine. Heterotrimeric G proteins regulated distinct signaling pathways, some of which in turn regulate the activity of Na+/H+ exchangers. This review describes the recent findings concerning the molecular mechanisms of the G-protein-dependent regulation of Na+/H+ exchangers.</p>","PeriodicalId":79565,"journal":{"name":"Biological signals and receptors","volume":"7 2","pages":"118-24"},"PeriodicalIF":0.0000,"publicationDate":"1998-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000014537","citationCount":"8","resultStr":"{\"title\":\"G proteins and Na+/H+ exchange.\",\"authors\":\"T A Voyno-Yasenetskaya\",\"doi\":\"10.1159/000014537\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The Na+/H+ exchangers are important regulators of intracellular pH, cell volume, and cell proliferation. They exist in all cells with a cell-specific pattern of isoform expression. Na+/H+ exchangers are regulated by a variety of extracellular stimuli which activate G-protein-coupled receptors and receptor tyrosine. Heterotrimeric G proteins regulated distinct signaling pathways, some of which in turn regulate the activity of Na+/H+ exchangers. This review describes the recent findings concerning the molecular mechanisms of the G-protein-dependent regulation of Na+/H+ exchangers.</p>\",\"PeriodicalId\":79565,\"journal\":{\"name\":\"Biological signals and receptors\",\"volume\":\"7 2\",\"pages\":\"118-24\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1998-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1159/000014537\",\"citationCount\":\"8\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biological signals and receptors\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1159/000014537\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biological signals and receptors","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1159/000014537","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The Na+/H+ exchangers are important regulators of intracellular pH, cell volume, and cell proliferation. They exist in all cells with a cell-specific pattern of isoform expression. Na+/H+ exchangers are regulated by a variety of extracellular stimuli which activate G-protein-coupled receptors and receptor tyrosine. Heterotrimeric G proteins regulated distinct signaling pathways, some of which in turn regulate the activity of Na+/H+ exchangers. This review describes the recent findings concerning the molecular mechanisms of the G-protein-dependent regulation of Na+/H+ exchangers.