G蛋白和Na+/H+交换。

T A Voyno-Yasenetskaya
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引用次数: 8

摘要

Na+/H+交换剂是细胞内pH、细胞体积和细胞增殖的重要调节因子。它们存在于所有具有细胞特异性同种异构体表达模式的细胞中。Na+/H+交换物受多种胞外刺激调控,这些刺激可激活g蛋白偶联受体和酪氨酸受体。异三聚体G蛋白调节不同的信号通路,其中一些反过来调节Na+/H+交换器的活性。本文综述了近年来g蛋白依赖性Na+/H+交换体调控的分子机制研究进展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
G proteins and Na+/H+ exchange.

The Na+/H+ exchangers are important regulators of intracellular pH, cell volume, and cell proliferation. They exist in all cells with a cell-specific pattern of isoform expression. Na+/H+ exchangers are regulated by a variety of extracellular stimuli which activate G-protein-coupled receptors and receptor tyrosine. Heterotrimeric G proteins regulated distinct signaling pathways, some of which in turn regulate the activity of Na+/H+ exchangers. This review describes the recent findings concerning the molecular mechanisms of the G-protein-dependent regulation of Na+/H+ exchangers.

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