雌激素与肿瘤生长的遗传控制。

J Gorski, D Wendell, D Gregg, T Y Chun
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引用次数: 0

摘要

雌激素诱导的F344大鼠垂体肿瘤的生化和遗传学研究为了解肿瘤生物学提供了新的模型。由于这种动物模型中已经存在肿瘤易感的遗传差异,因此有可能寻找潜在的机制。有趣的是,到目前为止,已知或未知癌基因表达的显著变化似乎与这种肿瘤的形成无关。同样,已知的血管生成因子并没有涉及该模型对雌激素的戏剧性血管生成反应。解剖出这个系统中涉及的关键基因和产物,然后确定类似的基因是否与人类雌激素引起的癌症有关,这将是非常有用的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Estrogens and the genetic control of tumor growth.

Biochemical and genetic studies of the estrogen-induced pituitary tumors of the F344 rat provide a new model for understanding cancer biology. Because a genetic difference in tumor susceptibly already exists in this animal model it is possible to search for the underlying mechanisms. Interestingly, thus far marked changes in expression of known or unknown oncogenes do not appear to be involved in the formation of this tumor. Similarly, known angiogenic factors have not been implicated in this model's dramatic angiogenic response to estrogen. It will be very informative to dissect out the critical genes and the products that are involved in this system and then to determine whether similar genes are involved in human, estrogen-induced cancers.

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