利用遗传生物标志物确定乳腺癌的病因异质性。

T R Rebbeck, A H Walker, C M Phelan, A K Godwin, K H Buetow, J E Garber, S A Narod, B L Weber
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引用次数: 0

摘要

大多数乳腺癌具有复杂的多因素病因。这种多因素现象的一个后果是可能存在病因异质性。这种异质性仅仅意味着普通人群中两组或两组以上的乳腺癌病例可能是由不同的事件引起的。在人群中定义病因异质性亚群的能力可能促进许多研究和临床问题。在一般人群中研究病因同质亚群可以提高识别病因的能力。确定一组相同的乳腺癌病例也可能有助于乳腺癌的诊断或治疗,并可能允许更有效地应用癌症预防和控制策略。确定一般人群的病因异质性是了解癌症病因学过程中的第一步。利用上述两个例子所提供的知识,可以进行正式的病例对照或队列研究,以检查确定病因异质性的因素是否与病因学有关。此外,病因异质性的研究结果可以指向潜在的基因-基因或基因-环境相互作用。因此,这里提出的研究类型可以在导致更正式的分子流行病学分析方面发挥有益的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Defining etiologic heterogeneity in breast cancer using genetic biomarkers.

Most breast cancer has a complex, multifactorial etiology. One consequence of this multifactorial phenomenon is that etiological heterogeneity may exist. This heterogeneity implies simply that two or more groups of breast cancer cases in the general population may have been caused by different sets of events. The ability to define etiologically heterogeneous subgroups in the population may facilitate a number of research and clinical issues. Studying etiologically homogeneous subgroups in the general population may improve the ability to identify etiologic agents. Identification of a homogeneous group of breast cancer cases may also aid breast cancer diagnosis or treatment, and may allow a more effectively application of cancer prevention and control strategies. Defining etiologic heterogeneity in the general population is one initial step in the process of understanding cancer etiology. Using knowledge such as that provided in the two examples presented here, formal case-control or cohort studies can be undertaken to examine whether the factors that define etiologic heterogeneity are involved in etiology. Furthermore, the results of studies of etiologic heterogeneity can point toward potential gene-gene or gene-environment interactions. The type of studies presented here can therefore serve a useful role in leading to more formal molecular epidemiological analyses.

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