含色氨酸肽3(10)-螺旋的晶体学表征。

Peptide research Pub Date : 1996-11-01
C George, J L Flippen-Anderson, A Bianco, M Crisma, F Formaggio, C Toniolo
{"title":"含色氨酸肽3(10)-螺旋的晶体学表征。","authors":"C George,&nbsp;J L Flippen-Anderson,&nbsp;A Bianco,&nbsp;M Crisma,&nbsp;F Formaggio,&nbsp;C Toniolo","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>The molecular and crystal structures of four peptides containing one L-Trp guest residue in Aib (alpha-aminoisobutyric acid or C alpha-methyl alanine) host oligopeptide chains have been determined by X-ray diffraction. The peptides are Z-Aib-L-Trp-Aib-OMe, Z-(Aib)2-L-Trp-Aib-OMe, Z-(Aib)3-L-Trp-Aib-OtBu and Boc-(Aib)3-L-Trp-Aib-OMe. Right-handed beta-turns and incipient and fully developed 3(10)-helices are formed in the crystal state by the tri-, tetra- and pentapeptides, respectively. The Trp residue is easily accommodated in these folded structures. The average geometry and preferred conformation for the Trp indolyl side chain are also discussed.</p>","PeriodicalId":20005,"journal":{"name":"Peptide research","volume":"9 6","pages":"315-21"},"PeriodicalIF":0.0000,"publicationDate":"1996-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Crystallographic characterization of tryptophan-containing peptide 3(10)-helices.\",\"authors\":\"C George,&nbsp;J L Flippen-Anderson,&nbsp;A Bianco,&nbsp;M Crisma,&nbsp;F Formaggio,&nbsp;C Toniolo\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The molecular and crystal structures of four peptides containing one L-Trp guest residue in Aib (alpha-aminoisobutyric acid or C alpha-methyl alanine) host oligopeptide chains have been determined by X-ray diffraction. The peptides are Z-Aib-L-Trp-Aib-OMe, Z-(Aib)2-L-Trp-Aib-OMe, Z-(Aib)3-L-Trp-Aib-OtBu and Boc-(Aib)3-L-Trp-Aib-OMe. Right-handed beta-turns and incipient and fully developed 3(10)-helices are formed in the crystal state by the tri-, tetra- and pentapeptides, respectively. The Trp residue is easily accommodated in these folded structures. The average geometry and preferred conformation for the Trp indolyl side chain are also discussed.</p>\",\"PeriodicalId\":20005,\"journal\":{\"name\":\"Peptide research\",\"volume\":\"9 6\",\"pages\":\"315-21\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1996-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Peptide research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Peptide research","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

用x射线衍射测定了在Aib (α -氨基异丁酸或C - α -甲基丙氨酸)宿主寡肽链中含有1个L-Trp残基的4种多肽的分子和晶体结构。这些肽分别是Z-Aib- l - trp -Aib- ome、Z-(Aib)2-L-Trp-Aib-OMe、Z-(Aib)3-L-Trp-Aib-OtBu和Boc-(Aib)3-L-Trp-Aib-OMe。在晶体状态下,三肽、四肽和五肽分别形成了右旋β旋和初始和完全发育的3(10)-螺旋。色氨酸残基很容易在这些折叠结构中被容纳。还讨论了色氨酸吲哚基侧链的平均几何形状和优选构象。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Crystallographic characterization of tryptophan-containing peptide 3(10)-helices.

The molecular and crystal structures of four peptides containing one L-Trp guest residue in Aib (alpha-aminoisobutyric acid or C alpha-methyl alanine) host oligopeptide chains have been determined by X-ray diffraction. The peptides are Z-Aib-L-Trp-Aib-OMe, Z-(Aib)2-L-Trp-Aib-OMe, Z-(Aib)3-L-Trp-Aib-OtBu and Boc-(Aib)3-L-Trp-Aib-OMe. Right-handed beta-turns and incipient and fully developed 3(10)-helices are formed in the crystal state by the tri-, tetra- and pentapeptides, respectively. The Trp residue is easily accommodated in these folded structures. The average geometry and preferred conformation for the Trp indolyl side chain are also discussed.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信