fMLP类似物中酰胺键3位的修饰选择中性粒细胞功能。

Peptide research Pub Date : 1996-11-01

S Spisani, A Breveglieri, E Fabbri, G Vertuani, O Rizzuti, G Cavicchioni

{"title":"fMLP类似物中酰胺键3位的修饰选择中性粒细胞功能。","authors":"S Spisani, A Breveglieri, E Fabbri, G Vertuani, O Rizzuti, G Cavicchioni","doi":"","DOIUrl":null,"url":null,"abstract":"The formylpeptides formyl-L-methionyl-L-leucyl-L-N-methylphenylalanine methyl ester 1, formyl-L-methionyl-L-leucyl-L-2-oxy-3-phenylpropionic acid methyl ester 2 and formyl-L-methionyl-L-leucyl-L-2-aminoxy-3-phenylpropionic acid methyl ester 3 were synthesized to investigate the role of the amide bond at position 3 in biological activity in human neutrophiles. Our results indicate that this amide bond is required for optimal chemotactic activity, but not for superoxide anion production.","PeriodicalId":20005,"journal":{"name":"Peptide research","volume":"9 6","pages":"279-82"},"PeriodicalIF":0.0000,"publicationDate":"1996-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Modifications of the amide bond at position 3 in fMLP analogs select neutrophil functions.\",\"authors\":\"S Spisani, A Breveglieri, E Fabbri, G Vertuani, O Rizzuti, G Cavicchioni\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The formylpeptides formyl-L-methionyl-L-leucyl-L-N-methylphenylalanine methyl ester 1, formyl-L-methionyl-L-leucyl-L-2-oxy-3-phenylpropionic acid methyl ester 2 and formyl-L-methionyl-L-leucyl-L-2-aminoxy-3-phenylpropionic acid methyl ester 3 were synthesized to investigate the role of the amide bond at position 3 in biological activity in human neutrophiles. Our results indicate that this amide bond is required for optimal chemotactic activity, but not for superoxide anion production.\",\"PeriodicalId\":20005,\"journal\":{\"name\":\"Peptide research\",\"volume\":\"9 6\",\"pages\":\"279-82\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1996-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Peptide research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Peptide research","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

摘要

合成了甲酰基-l -蛋氨酸-l -亮氨酸-l - n -甲基苯基丙氨酸甲酯1、甲酰基-l -蛋氨酸-l -亮氨酸-l -2-氧-3-苯基丙酸甲酯2和甲酰基-l -蛋氨酸-l -亮氨酸-l -2-氨基-3-苯基丙酸甲酯3，研究了3位酰胺键在人中性粒细胞生物活性中的作用。我们的研究结果表明，这种酰胺键是最佳趋化活性所必需的，但不是超氧阴离子产生所必需的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

本刊更多论文

Modifications of the amide bond at position 3 in fMLP analogs select neutrophil functions.

The formylpeptides formyl-L-methionyl-L-leucyl-L-N-methylphenylalanine methyl ester 1, formyl-L-methionyl-L-leucyl-L-2-oxy-3-phenylpropionic acid methyl ester 2 and formyl-L-methionyl-L-leucyl-L-2-aminoxy-3-phenylpropionic acid methyl ester 3 were synthesized to investigate the role of the amide bond at position 3 in biological activity in human neutrophiles. Our results indicate that this amide bond is required for optimal chemotactic activity, but not for superoxide anion production.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Peptide research

自引率

0.00%

发文量