{"title":"哺乳动物醛脱氢酶:基因表达调控。","authors":"R Lindahl","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>The mammalian aldehyde dehydrogenases (ALDH) are a family of functionally and structurally related enzymes encoded by multiple genes. Genes representing each major class of mammalian ALDHs, Class 1, 2 and 3, have been cloned and characterized. Functional analysis of the 5' flanking regions of these genes is just beginning, but such studies suggest roles for a diverse set of cis-elements and trans-acting factors in the tissue-specific and ligand-mediated expression of the ALDH genes.</p>","PeriodicalId":7689,"journal":{"name":"Alcohol and alcoholism (Oxford, Oxfordshire). Supplement","volume":"2 ","pages":"147-54"},"PeriodicalIF":0.0000,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Mammalian aldehyde dehydrogenases: regulation of gene expression.\",\"authors\":\"R Lindahl\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The mammalian aldehyde dehydrogenases (ALDH) are a family of functionally and structurally related enzymes encoded by multiple genes. Genes representing each major class of mammalian ALDHs, Class 1, 2 and 3, have been cloned and characterized. Functional analysis of the 5' flanking regions of these genes is just beginning, but such studies suggest roles for a diverse set of cis-elements and trans-acting factors in the tissue-specific and ligand-mediated expression of the ALDH genes.</p>\",\"PeriodicalId\":7689,\"journal\":{\"name\":\"Alcohol and alcoholism (Oxford, Oxfordshire). Supplement\",\"volume\":\"2 \",\"pages\":\"147-54\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1994-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Alcohol and alcoholism (Oxford, Oxfordshire). Supplement\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Alcohol and alcoholism (Oxford, Oxfordshire). Supplement","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Mammalian aldehyde dehydrogenases: regulation of gene expression.
The mammalian aldehyde dehydrogenases (ALDH) are a family of functionally and structurally related enzymes encoded by multiple genes. Genes representing each major class of mammalian ALDHs, Class 1, 2 and 3, have been cloned and characterized. Functional analysis of the 5' flanking regions of these genes is just beginning, but such studies suggest roles for a diverse set of cis-elements and trans-acting factors in the tissue-specific and ligand-mediated expression of the ALDH genes.
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