冠状动脉病患者血清的氧化修饰

R Bakalova, A Goudev, Z Zhelev, C Nachev
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引用次数: 0

摘要

研究了有和没有冠状动脉疾病的人血清的氧化修饰。分析4个参数:血清荧光强度,反映脂褐素样脂质过氧化产物的含量;硫代巴比妥酸反应物质含量;偶氮化合物氧化血清的滞后期;以及亲脂性天然抗氧化剂的含量——α -生育酚、β -胡萝卜素和泛醇9(10)。结果发现,冠状动脉病变导致血清荧光和TBARS含量显著升高。冠状动脉疾病患者的动脉粥样硬化性疾病在2,2'-偶氮-双-(2-氨基丙烷)盐酸存在下显著降低了血清氧化的滞后期。血清的氧化修饰与血清中天然亲脂性抗氧化剂(α -生育酚、泛醇和β -胡萝卜素)的平衡密切相关。冠状动脉疾病患者血清中所有抗氧化剂的含量均显著降低。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Oxidative modifications of blood serum in humans with coronary artery disease.

Oxidative modifications of blood serum in humans with and without coronary artery disease were investigated. Four parameters were analyzed: the intensity of serum fluorescence, which is indicative of the content of lipofuscine-like lipid peroxidation products; the content of thiobarbituric acid-reactive substances; the lag-phase of serum oxidation by azo-compounds; and the content of lipophilic natural antioxidants--alpha-tocopherol, beta-carotene and ubiquinol-9(10). It was found that coronary artery disease resulted in a significant increase of serum fluorescence and the content of TBARS. The atherogenic disorders in humans with coronary artery disease drastically decreased the lag-phase of serum oxidation in the presence of 2,2'-azo-bis-(2-amidinopropane) dihydrochloride. The oxidative modifications of serum were in close correlation with the balance of natural lipophilic antioxidants in blood serum, i.e. alpha-tocopherol, ubiquinols and beta-carotene. The contents of all antioxidants tested in serum were significantly decreased in patients with coronary artery disease.

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