[儿童急性淋巴细胞白血病缓解过程中血液免疫参数的回顾性评价]。

IF 0.2 4区 医学 Q4 HEMATOLOGY
Gematologiya I Transfuziologiya Pub Date : 1996-03-01
N S Kisliak, R V Lenskaia, E Iu Shvedova, G V Kolenkova, K L Kondratchik, N A Finogenova, E A Mamedova, A M Akk, Ia Ia Lutskaia, E N Dolgina, A A Afanas'eva, L Kh Pronina
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引用次数: 0

摘要

作者研究了53例3岁以上急性淋巴细胞白血病患儿的细胞免疫和体液免疫。患儿病情缓解期为6 ~ 120个月,诊断后随访7 ~ 14年。根据1981-1988年的综合化疗方案进行治疗。1995年11月,42名儿童存活,其中15人患病10年。淋巴细胞减少(t细胞和b细胞的绝对数量分别下降3-5倍和2-3倍)在早期缓解和晚期(6-12个月,24-60个月,60个月和更长时间)所有的考生报告。在早期缓解中,血清IgG、IgA和IgM显著降低。在急性淋巴细胞白血病致死性结局患儿中,血清IgM和E-RFCa绝对数量在缓解早期下降更为显著,表明药物引起的淋巴细胞生成深度抑制。治疗5年后,外周血T淋巴细胞池和T/B淋巴细胞比例变化最好,但绝对数量低于正常水平。血清IgG、IgA及循环免疫复合物高于正常1.3 ~ 1.5倍,可能与胃肠道病理及食物过敏有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Retrospective evaluation of blood immunologic parameters in the course of remission of acute lymphoblastic leukemia in children].

The authors investigated cellular and humoral immunity in 53 children over 3 years of age suffering from acute lymphoblastic leukemia. The children had remission lasting from 6 to 120 months and were followed up for 7-14 years after the diagnosis was made. The treatment was performed according to programs of polychemotherapy practiced in 1981-1988. In November of 1995 42 children were alive, 15 had the disease for 10 years. Lymphocytopenia (absolute number of T-cells and B-cells fell 3-5 and 2-3-fold, respectively) was reported in all the examinees both in early remission and later (6-12, 24-60, 60 and more months since the disease onset). In early remission there was a significant reduction in the serum IgG, IgA and IgM. In children with ALL lethal outcome serum IgM and absolute number of E-RFCa dropped in early remission more significantly indicating deep drug-induced depression of lymphocytopoiesis. After 5 years of treatment the pool of peripheral T-lymphocytes and T/B lymphocyte proportion changed for the best, though their absolute number was subnormal. Serum IgG, IgA and circulating immune complexes were 1.3-1.5 times higher than normal which may be explained by gastrointestinal pathology and food allergy in the majority of children treated.

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来源期刊
CiteScore
0.80
自引率
66.70%
发文量
29
审稿时长
>12 weeks
期刊介绍: The journal publishes original theoretical and clinical studies, lectures, reviews, and practical notes concerning various problems of hematology and clinical and industrial transfusion. The journal provides information on the etiology, pathogenesis, diagnosis and treatment of blood disorders as well as on related non-hematological conditions (internal diseases, poisoning, exposure to ionizing radiation etc.).
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