琥珀酸铁蛋白(itf282)的化学和生物学特性。

P Cremonesi, I Caramazza
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引用次数: 0

摘要

itf282是一种铁琥珀酰酪蛋白复合物,含铁5%。该衍生物的主要特性是在酸性pH值下保持铁结合。这说明在治疗缺铁期间,与铁盐相比,该化合物具有更好的耐受性。正常和贫血大鼠的药理学研究表明,这种铁复合物对缺铁性贫血的作用几乎与硫酸亚铁一样有效,但在增加血清铁方面的作用明显较弱。itf282在大鼠和狗身上表现出更好的胃肠道耐受性。介绍了琥珀酸铁蛋白的化学和药理性质。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Chemical and biological characterization of iron-protein succinylate (ITF 282).

ITF 282 is an iron succinyl casein complex containing 5% iron. The main property of the derivative is to keep iron bonded at acidic pH values. This accounts for a better tolerability of the compound compared with iron salts, during the treatment of iron deficiency. Pharmacological studies in normal and anemic rats demonstrated that this iron complex is almost as active as ferrous sulphate against iron deficiency anemia, but it is significantly less potent in increasing serum iron. Better gastrointestinal tolerability of ITF 282 was demonstrated in rats and dogs. Chemical and pharmacological properties of iron-protein succinylate are described.

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