{"title":"兴奋性氨基酸受体与癫痫。","authors":"J O McNamara","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>The rapid pace of discovery in the molecular biology of glutamate receptors includes advances concerning the N-methyl-D-aspartate receptor. New information emerging in this area is already affecting the study of epilepsy in animal models and provides novel opportunities to extrapolate directly to human disease through isolation and chromosomal localization of human glutamate receptor genes. These discoveries are being exploited for improved understanding and treatment of human epilepsy.</p>","PeriodicalId":77089,"journal":{"name":"Current opinion in neurology and neurosurgery","volume":"6 4","pages":"583-7"},"PeriodicalIF":0.0000,"publicationDate":"1993-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Excitatory amino acid receptors and epilepsy.\",\"authors\":\"J O McNamara\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The rapid pace of discovery in the molecular biology of glutamate receptors includes advances concerning the N-methyl-D-aspartate receptor. New information emerging in this area is already affecting the study of epilepsy in animal models and provides novel opportunities to extrapolate directly to human disease through isolation and chromosomal localization of human glutamate receptor genes. These discoveries are being exploited for improved understanding and treatment of human epilepsy.</p>\",\"PeriodicalId\":77089,\"journal\":{\"name\":\"Current opinion in neurology and neurosurgery\",\"volume\":\"6 4\",\"pages\":\"583-7\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1993-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current opinion in neurology and neurosurgery\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current opinion in neurology and neurosurgery","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
谷氨酸受体分子生物学的快速发现包括n -甲基- d -天冬氨酸受体的进展。这一领域出现的新信息已经影响到癫痫动物模型的研究，并为通过分离和人类谷氨酸受体基因的染色体定位直接推断人类疾病提供了新的机会。这些发现正被用于增进对人类癫痫的了解和治疗。
The rapid pace of discovery in the molecular biology of glutamate receptors includes advances concerning the N-methyl-D-aspartate receptor. New information emerging in this area is already affecting the study of epilepsy in animal models and provides novel opportunities to extrapolate directly to human disease through isolation and chromosomal localization of human glutamate receptor genes. These discoveries are being exploited for improved understanding and treatment of human epilepsy.
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