乙醇对人脑皮层gtp结合蛋白功能的影响

Arukoru kenkyu to yakubutsu izon = Japanese journal of alcohol studies & drug dependence Pub Date : 1993-04-01

H Ozawa, Y Katamura, E Hashimoto, S Hatta, T Saito, P Riederer, N Takahata

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引用次数: 0

摘要

采用抗光亲和水解GTP类似物(azidoanilido GTP, AAGTP)，分析了乙醇“体外”对死后人脑皮层膜GTP结合蛋白的影响。AAGTP在人脑皮层膜中鉴定出刺激性GTP结合蛋白[Gs α (42 KDa)]和抑制性GTP结合蛋白[Gi α (40 KDa)]。乙醇增加了AAGTP与人类颞叶和顶叶皮层中Gs α和Gi α的结合量。这些结果表明，乙醇“体外”不仅能提高死后人脑皮层的Gs功能，还能提高Gi功能。

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[Effects of ethanol on GTP-binding protein function in human brain cortex].

The effect of ethanol "in vitro" on GTP-binding protein in postmortem human brain cortex membranes was analyzed using by photoaffinity hydrolysis resistant GTP analog (azidoanilido GTP, AAGTP). AAGTP identified stimulatory GTP binding protein [Gs alpha (42 KDa)] and inhibitory GTP binding protein [Gi alpha (40 KDa)] in human brain cortex membranes. Ethanol augmented the amount of AAGTP binding to both Gs alpha and Gi alpha in human temporal and parietal cortex membranes. These results show that ethanol "in vitro" elevates not only Gs functions but also Gi functions in postmortem human brain cortex.

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Arukoru kenkyu to yakubutsu izon = Japanese journal of alcohol studies & drug dependence

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