T Nabeshima, Y Maeda, K Yamada, T Nakamura, T Hasegawa
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引用次数: 0
摘要
研究鲑鱼降钙素(SCT)对鞘内注射n -甲基- d -天冬氨酸(NMDA)诱导的厌恶行为的影响，以阐明NMDA受体/离子载体复合物参与SCT的镇痛作用。脑室内注射SCT显著抑制醋酸致扭体。鞘内注射NMDA (0.25-1.0 nmol/小鼠)剂量依赖性诱导了如抓挠和咬尾等厌恶行为。0.01和0.1 IU/小鼠(i.c.v)剂量的SCT显著抑制nmda诱导的厌恶行为。皮下注射MK-801和NMDA既没有增强也没有拮抗SCT对NMDA诱导的厌恶行为的抑制作用。此外，MK-801 (i.c.v)和NMDA (i.c.v)本身不影响NMDA (i.c.v)诱导的厌恶行为。这些结果表明，脑内NMDA受体/离子载体复合物并不直接参与脑内注射SCT的抗感觉作用。
The inhibitory effects of salmon calcitonin on intrathecally-injected N-methyl-D-aspartate-induced aversive behavior in mice.
The effects of salmon calcitonin (SCT) on intrathecally-injected N-methyl-D-aspartate (NMDA)-induced aversive behavior were investigated to clarify the involvement of the NMDA receptor/ionophore complex on the analgesic effects of SCT. Intracerebroventricular (i.c.v.) injection of SCT significantly inhibited acetic acid-induced writhing. Intrathecal (i.t.) injection of NMDA (0.25-1.0 nmol/mouse) dose-dependently induced aversive behavior such as scratching and tail biting. SCT at the doses of 0.01 and 0.1 IU/mouse (i.c.v.) significantly inhibited the NMDA-induced aversive behavior. This inhibitory effects of SCT on NMDA (i.t.)-induced aversive behavior were neither potentiated nor antagonized by i.c.v. injection of MK-801 and NMDA, respectively. Further, MK-801 (i.c.v.) and NMDA (i.c.v.) themselves did not affect the NMDA (i.t.)-induced aversive behavior. These results suggest that the NMDA receptor/ionophore complex in the brain is not directly involved in the antinociceptive effects of intracerebrally-injected SCT.
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