昂丹司琼作为药物前用药的评价。

E Kamenova
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引用次数: 0

摘要

在一项临床试验中,研究了一种高度特异性的5HT3拮抗剂Ondansetron (Zofran, Glaxo)在预防引入麻醉过程中非常不利的并发症(即Bezold-Jarisch反射样反应)方面的效力。共20例接受临床手术治疗的患者(男12例,女8例,年龄19-65岁)参加试验。插管前1小时静脉注射Zofran (8mg, 500 ml林格氏液),流速为8ml . min-1。连续观察收缩压和舒张压、中心静脉压、呼吸频率和分次通气量、静脉血pCO2和pO2、心电图(ECG)以及自发肌肉活动、眼睑反射、皮肤和粘膜表面等共同特征。对肺部进行了视觉、听诊和x线检查。发现阻断5HT3受体可阻止Bezold-Jarisch反射样反应的发生。该药物可成功用于麻醉实践。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Evaluation of ondansetron as a drug for premedication.

The potency of Ondansetron (Zofran, Glaxo), a highly specific 5HT3 antagonist in preventing the very unfavorable complication during introducing anesthesia, i.e. a Bezold-Jarisch reflex-like reaction, was studied in a clinical trial. A total of 20 patients (12 males and 8 females aged 19-65 years) admitted for clinical surgical treatment participated in the trial. Zofran (8 mg in 500 ml Ringer solution) was injected intravenously one hour before intubation at a flow rate of 8 ml. min-1. Systolic and diastolic blood pressure, central venous pressure, breathing frequency and minute ventilation, pCO2 and pO2 in venous blood, electrocardiogram monitoring (ECG) and several common features such as spontaneous muscle activity, palpebral reflexes, skin and mucose surfaces were continuously observed. Visual, auscultatory and X-ray control of the lungs was effected. It was found that blockade of 5HT3 receptors prevented the appearance of Bezold-Jarisch reflex-like reaction. The drug could successfully be used in anesthesiological practice.

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