[The effect of flumazenil administration on acute cocaine intoxication of rats].

Flumazenil was studied on cocaine intoxicated rats for its preventive effect on seizure, death and loss of righting reflex. Two minutes after the intraperitoneal injection of cocaine (70 mg/kg) into a rat, flumazenil and diazepam were administered at the clinically corresponding dose intraperitoneally. Flumazenil at a dose 0.125 mg/kg extended the onset time of the cocaine induced seizure. Flumazenil at 0.5 or 1.0 mg/kg with diazepam 2.0 mg/kg, prevented the seizure, and kept righting reflex. It was observed that use of flumazenil in combination with cocaine had the effect of the benzodiazepine receptor.