酒精中毒与乙醛代谢酶基因型的关系

Arukoru kenkyu to yakubutsu izon = Japanese journal of alcohol studies & drug dependence Pub Date : 1994-02-01

K Iwahashi, K Nakamura, H Suwaki, R Miyatake, Y Matsuo, Y Ichikawa, K Orino

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引用次数: 0

摘要

研究了饮酒和非饮酒(健康)日本人CYP2E1和ALDH2基因座的基因型，探讨了CYP2E1 (C1/C2)和ALDH2 (ALDH2*1/ALDH2*2)多态性与酒精中毒易感性的关系。酗酒者和非酗酒者的C2基因频率差异无统计学意义(0.20)，而ALDH2等位基因频率差异有统计学意义(0.19)，提示CYP2E1的C2等位基因可能与日本人酒精中毒的发生风险无关，而ALDH2*1等位基因可能影响饮酒行为和酒精中毒的发生。

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[Relationship between alcoholism and genotypes of acetaldehyde-metabolizing enzymes].

The genotypes of the CYP2E1 and ALDH2 loci in alcoholic and non-alcoholic (healthy) Japanese were investigated to examine the relationship between the polymorphisms of CYP2E1 (C1/C2) and ALDH2 (ALDH2*1/ALDH2*2), and the susceptibility to alcoholism. There was no significant difference in C2 gene frequency between alcoholics (0.20) and non-alcoholics (0.19), while there was a significant difference in ALDH2 allele frequency, suggesting that the C2 allele of CYP2E1 may have nothing to the risk of developing alcoholism in Japanese, whereas the ALDH2*1 allele may influence drinking behavior and the development of alcoholism.

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Arukoru kenkyu to yakubutsu izon = Japanese journal of alcohol studies & drug dependence

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