{"title":"老年性痴呆神经病理相关的益智药物及其作用机制。2膜完整性和神经元代谢紊乱]。","authors":"O Benesová","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>The author discusses several newer aspects concerning neurodegenerative processes in nerve cells of aging brain on the level of membrane integrity and neuronal metabolism disturbances: aggressive impact of free radicals and excitatory amino acids, loss of calcium homeostasis, deposition of amyloid proteins. Perspective nootropic agents are presented which were synthetized with the aim to regulate these deficits and first clinical experience with their administration in senile dementia patients is evaluated.</p>","PeriodicalId":75693,"journal":{"name":"Ceskoslovenska psychiatrie","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1994-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"[Nooptropic agents and their action mechanisms in relation to neuropathology in senile dementia. II. Disorders of membrane integrity and neuron metabolism].\",\"authors\":\"O Benesová\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The author discusses several newer aspects concerning neurodegenerative processes in nerve cells of aging brain on the level of membrane integrity and neuronal metabolism disturbances: aggressive impact of free radicals and excitatory amino acids, loss of calcium homeostasis, deposition of amyloid proteins. Perspective nootropic agents are presented which were synthetized with the aim to regulate these deficits and first clinical experience with their administration in senile dementia patients is evaluated.</p>\",\"PeriodicalId\":75693,\"journal\":{\"name\":\"Ceskoslovenska psychiatrie\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1994-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Ceskoslovenska psychiatrie\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Ceskoslovenska psychiatrie","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
[Nooptropic agents and their action mechanisms in relation to neuropathology in senile dementia. II. Disorders of membrane integrity and neuron metabolism].
The author discusses several newer aspects concerning neurodegenerative processes in nerve cells of aging brain on the level of membrane integrity and neuronal metabolism disturbances: aggressive impact of free radicals and excitatory amino acids, loss of calcium homeostasis, deposition of amyloid proteins. Perspective nootropic agents are presented which were synthetized with the aim to regulate these deficits and first clinical experience with their administration in senile dementia patients is evaluated.
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