[醛脱氢酶2基因型与饮酒的关系]。

T Ishibashi, S Harada, S Tanimura, F Taguchi
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引用次数: 0

摘要

利用等位基因特异性引物,对630名无亲缘关系的日本成年人进行了大规模人群调查,测定了醛脱氢酶2 (ALDH2)基因型。三种基因型频率分别为:60% ALDH2*1/ALDH2*1 (NN)型、35% ALDH2*1/ALDH2*2 (ND)型和5% ALDH2*2/ALDH2*2 (dd)型。三种基因型的月平均酒精消费量分别为:NN型965.8 g/月、ND型629.5 g/月和DD型179 g/月。3个遗传组间平均酒精消费量差异显著(p < 0.01)。当分别对这三组的男性和女性数据进行分析时,发现三组之间在性别上都存在显著差异。这些结果表明,ALDH2突变体是限制酒精消耗的重要遗传因素。ALDH2基因型的频率在男性和女性人群之间没有显著差异,但他们的平均饮酒量在两组之间有显著差异。因此,除了遗传因素外,各种社会因素和生活方式可能会影响饮酒量的差异。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Association among genotypes of aldehyde dehydrogenase 2 and alcohol consumption].

A large population survey was made for the determination of aldehyde dehydrogenase 2 (ALDH2) genotypes among 630 unrelated Japanese adults by PCR using allele specific primers. The frequencies of three genotypes were 60% ALDH2*1/ALDH2*1 (NN) type, 35% ALDH2*1/ALDH2*2 (ND) type and 5% ALDH2*2/ALDH2*2 (dd) type. Average amounts of alcohol consumption per month for three genotypes were 965.8 g/month for NN type, 629.5 g/month for ND type and 179 g/month for DD type. The differences in average alcohol consumption were significant (p < 0.01) among the three genetic different groups. When male and female date were analyzed separately for these three groups, significant differences among three groups were found in both genders. These results indicated that ALDH2 mutant is an important genetic factor for limiting the alcohol consumption. The frequencies of ALDH2 genotypes were not significantly different between male and female population groups, however, their average alcohol consumption were significantly different between the two groups. Therefore, various social factors and life styles, in addition to genetic factors, might concern in the difference of alcohol consumption.

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