[b细胞抑制因子和红细胞抑制因子对造血干细胞集落形成能力的影响]。

IF 0.2 4区医学 Q4 HEMATOLOGY

Gematologiya I Transfuziologiya Pub Date : 1995-01-01

I A Lisukov, S K Khaldoianidi, M A Tikhonova, E R Chernykh, V A Kozlov

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引用次数: 0

摘要

研究了健康供者和淋巴细胞增生性疾病患者造血前体克隆及其在两种新型抑制因子(BSF和ErSF)的调控作用。结果表明，非霍奇金淋巴瘤患者外周血中红细胞前体细胞的计数高于粒细胞-巨噬细胞前体细胞的计数。BSF完全抑制粒细胞-巨噬细胞、巨噬细胞和红细胞集落生长。相反，ErSF选择性地抑制红前体细胞的增殖和分化。讨论了上述因子在淋巴细胞增生性疾病中正常造血抑制机制中的作用。

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本刊更多论文

[Effect of B-cell suppressor factor and erythroblast suppressor factor on the colony-forming capacity of hematopoietic stem cells].

Hemopoietic precursor cloning in healthy donors and patients with lymphoproliferative disorders and its regulation in donors by two novel suppressive factors (BSF and ErSF) are investigated. It is shown that the count of erythroid precursors is increased in peripheral blood of patients with non-Hodgkin's lymphoma in contrast to the count of granulocyte-macrophage precursors. BSF inhibits entirely granulocyte-macrophage, macrophage and erythrocyte colony growth. In contrast, ErSF abrogates selectively erythroid precursor cell proliferation and differentiation. The role of the above factor in normal hemopoiesis inhibition mechanism during lymphoproliferative diseases are discussed.

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来源期刊

Gematologiya I Transfuziologiya 医学-血液学

CiteScore

0.80

自引率

66.70%

发文量

审稿时长

>12 weeks

期刊介绍： The journal publishes original theoretical and clinical studies, lectures, reviews, and practical notes concerning various problems of hematology and clinical and industrial transfusion. The journal provides information on the etiology, pathogenesis, diagnosis and treatment of blood disorders as well as on related non-hematological conditions (internal diseases, poisoning, exposure to ionizing radiation etc.).