Enrico Pierangelli , Victor A. Levin , Jerome Seidenfeld , Laurence J. Marton
{"title":"猫脑腐胺扩散及大鼠脑毛细血管通透性:与脑肿瘤患者脑脊液腐胺水平的关系","authors":"Enrico Pierangelli , Victor A. Levin , Jerome Seidenfeld , Laurence J. Marton","doi":"10.1016/0014-2964(81)90028-1","DOIUrl":null,"url":null,"abstract":"<div><p>Cerebrospinal fluid (CSF) putrescine (Pu) levels are extremely useful measures of active tumor growth in patients harboring medulloblastoma but not in patients harboring most supratentorial malignant gliomas. This study was designed to determine the diffusion coefficient (<em>D</em>) for Pu in cat brain and the capillary permeability coefficient (<em>P</em><sub><em>c</em></sub>) in rat brain to explain the failure of supratentorial gliomas to manifest a consistent increase in CSF Pu with progressive tumor growth. The <em>P</em><sub><em>c</em></sub> for Pu was found to be greater than the <em>P</em><sub><em>c</em></sub> for urea, while the apparent brain <em>D</em> for Pu was lower than that for urea. This implies that Pu crosses capillaries and enters cells more rapidly than urea, which would reduce the amount of Pu that might ultimately reach the CSF by diffusion from tumor. These data explain why CSF levels of Pu are correlated best in medulloblastoms—generally located adjacent to the CSF pathways—and why levels are correlated least in malignant supratentorial gliomas—usually located within the brain hemispheres, from which diffusion to the ventricles and into the CSF would be difficult.</p></div>","PeriodicalId":100497,"journal":{"name":"European Journal of Cancer (1965)","volume":"17 2","pages":"Pages 143-147"},"PeriodicalIF":0.0000,"publicationDate":"1981-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0014-2964(81)90028-1","citationCount":"12","resultStr":"{\"title\":\"Putrescine diffusion in cat brain and capillary permeability in rat brain: Relation to CSF putrescine levels in brain tumor patients\",\"authors\":\"Enrico Pierangelli , Victor A. Levin , Jerome Seidenfeld , Laurence J. Marton\",\"doi\":\"10.1016/0014-2964(81)90028-1\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Cerebrospinal fluid (CSF) putrescine (Pu) levels are extremely useful measures of active tumor growth in patients harboring medulloblastoma but not in patients harboring most supratentorial malignant gliomas. This study was designed to determine the diffusion coefficient (<em>D</em>) for Pu in cat brain and the capillary permeability coefficient (<em>P</em><sub><em>c</em></sub>) in rat brain to explain the failure of supratentorial gliomas to manifest a consistent increase in CSF Pu with progressive tumor growth. The <em>P</em><sub><em>c</em></sub> for Pu was found to be greater than the <em>P</em><sub><em>c</em></sub> for urea, while the apparent brain <em>D</em> for Pu was lower than that for urea. This implies that Pu crosses capillaries and enters cells more rapidly than urea, which would reduce the amount of Pu that might ultimately reach the CSF by diffusion from tumor. These data explain why CSF levels of Pu are correlated best in medulloblastoms—generally located adjacent to the CSF pathways—and why levels are correlated least in malignant supratentorial gliomas—usually located within the brain hemispheres, from which diffusion to the ventricles and into the CSF would be difficult.</p></div>\",\"PeriodicalId\":100497,\"journal\":{\"name\":\"European Journal of Cancer (1965)\",\"volume\":\"17 2\",\"pages\":\"Pages 143-147\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1981-02-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0014-2964(81)90028-1\",\"citationCount\":\"12\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"European Journal of Cancer (1965)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/0014296481900281\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Journal of Cancer (1965)","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0014296481900281","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Putrescine diffusion in cat brain and capillary permeability in rat brain: Relation to CSF putrescine levels in brain tumor patients
Cerebrospinal fluid (CSF) putrescine (Pu) levels are extremely useful measures of active tumor growth in patients harboring medulloblastoma but not in patients harboring most supratentorial malignant gliomas. This study was designed to determine the diffusion coefficient (D) for Pu in cat brain and the capillary permeability coefficient (Pc) in rat brain to explain the failure of supratentorial gliomas to manifest a consistent increase in CSF Pu with progressive tumor growth. The Pc for Pu was found to be greater than the Pc for urea, while the apparent brain D for Pu was lower than that for urea. This implies that Pu crosses capillaries and enters cells more rapidly than urea, which would reduce the amount of Pu that might ultimately reach the CSF by diffusion from tumor. These data explain why CSF levels of Pu are correlated best in medulloblastoms—generally located adjacent to the CSF pathways—and why levels are correlated least in malignant supratentorial gliomas—usually located within the brain hemispheres, from which diffusion to the ventricles and into the CSF would be difficult.