{"title":"氯丙嗪对下丘脑内侧基底完全去神经化大鼠下丘脑血清素水平的逆转作用。","authors":"Z Bánky, B Halász","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>The effect of chlorpromazine (CPZ) treatment, the complete deafferentation of the medial basal hypothalamus (MBH) and their combination on 5-HT, DA and NE levels of the MBH, hypothalamic structures outside the MBH (RH), mesencephalon and amygdala were studied. Monoamines were determined by fluorimetry. CPZ reduced 5-HT in the hypothalamus (MBH, RH), DA in the amygdala and NE concentration in the RH. Complete deafferentation of the MBH decreased 5-HT in the MBH, DA in the amygdala and NE in the hypothalamus. CPZ + deafferentation of the MBH increased 5-HT concentrations in the hypothalamus (MBH and RH) and mesencephalon, and depressed DA levels in the amygdala and NE in the hypothalamus. The data suggest that the interruption of the neural connections of the MBH results in an inverse response of the hypothalamic serotoninergic elements to CPZ.</p>","PeriodicalId":7056,"journal":{"name":"Acta biologica Academiae Scientiarum Hungaricae","volume":"31 1-3","pages":"25-32"},"PeriodicalIF":0.0000,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Reversed effect of chlorpromazine on hypothalamic serotonin levels of rats with complete deafferentation of the medial basal hypothalamus.\",\"authors\":\"Z Bánky, B Halász\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The effect of chlorpromazine (CPZ) treatment, the complete deafferentation of the medial basal hypothalamus (MBH) and their combination on 5-HT, DA and NE levels of the MBH, hypothalamic structures outside the MBH (RH), mesencephalon and amygdala were studied. Monoamines were determined by fluorimetry. CPZ reduced 5-HT in the hypothalamus (MBH, RH), DA in the amygdala and NE concentration in the RH. Complete deafferentation of the MBH decreased 5-HT in the MBH, DA in the amygdala and NE in the hypothalamus. CPZ + deafferentation of the MBH increased 5-HT concentrations in the hypothalamus (MBH and RH) and mesencephalon, and depressed DA levels in the amygdala and NE in the hypothalamus. The data suggest that the interruption of the neural connections of the MBH results in an inverse response of the hypothalamic serotoninergic elements to CPZ.</p>\",\"PeriodicalId\":7056,\"journal\":{\"name\":\"Acta biologica Academiae Scientiarum Hungaricae\",\"volume\":\"31 1-3\",\"pages\":\"25-32\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1980-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Acta biologica Academiae Scientiarum Hungaricae\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta biologica Academiae Scientiarum Hungaricae","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Reversed effect of chlorpromazine on hypothalamic serotonin levels of rats with complete deafferentation of the medial basal hypothalamus.
The effect of chlorpromazine (CPZ) treatment, the complete deafferentation of the medial basal hypothalamus (MBH) and their combination on 5-HT, DA and NE levels of the MBH, hypothalamic structures outside the MBH (RH), mesencephalon and amygdala were studied. Monoamines were determined by fluorimetry. CPZ reduced 5-HT in the hypothalamus (MBH, RH), DA in the amygdala and NE concentration in the RH. Complete deafferentation of the MBH decreased 5-HT in the MBH, DA in the amygdala and NE in the hypothalamus. CPZ + deafferentation of the MBH increased 5-HT concentrations in the hypothalamus (MBH and RH) and mesencephalon, and depressed DA levels in the amygdala and NE in the hypothalamus. The data suggest that the interruption of the neural connections of the MBH results in an inverse response of the hypothalamic serotoninergic elements to CPZ.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
