顺铂(2)氯化二胺在宫颈鳞状细胞癌中的化疗敏感性试验。

Diagnostic gynecology and obstetrics Pub Date : 1982-01-01
K Yannopoulos, C J Cohen, G Deppe, S B Gusberg
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引用次数: 0

摘要

预防性帕帕尼科劳试验有助于诊断宫颈发育不良和原位癌,治愈率为100%。手术和放疗显著改善了1期和2期病变的数量和生活质量。然而,第三和第四阶段的结果几乎没有改善。全身化疗为控制病情提供了希望。大多数药物对宫颈鳞状细胞癌无效。顺铂(2)二胺氯化铂(DDP)的实验和临床试验显示对宫颈癌有效。为了使治疗个性化,化学敏感性试验(CST)被应用于类似于放射敏感性试验(RST)。基本上,研究了对照活检和DDP活检的测试后剂量,以评估使用客观形态学标准的反应。这种安全,相对简单,临床上适用的方法为选择患者和监测治疗提供了客观的维度。一个重要的观察结果使这项研究具有原始的真实性,即放疗和化疗以相同的方式影响细胞。这种相似的形态学反应很可能意味着肿瘤细胞损伤和坏死的类似生物学表达。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Chemosensitivity testing with CIS-platinum (2) diamminedichloride in squamous cell carcinoma of the cervix uteri.

The prophylactic Papanicolaou Test contributes in diagnosing dysplasias and carcinoma in situ of the uterine cervix with a realistic 100% cure. Surgery and radiotherapy improved considerably quantity and quality of life in stages 1 and 2 lesions. However, stages 3 and 4 have shown little improvement in results. Systemic treatment with chemotherapy offers hope for control. Most of the drugs are ineffective against squamous cell carcinoma of the cervix. Experimental and clinical trials with CIS-platinum (2) diamminedichloride (DDP) show effectiveness against cervical carcinoma. In an effort to individualize the treatment, a chemosensitivity testing (CST) is applied analogous to the radiosensitivity testing (RST). Basically, a control biopsy and posttest dose of DDP biopsies are studied to evaluate the response using objective morphological criteria. This safe, relatively simple, clinically applicable approach offers an objective dimension in selecting the patients and in monitoring the treatment. An important observation that gives this study an original authenticity is the fact that radiation and chemotherapy affects the cells in an identical way. This similar morphological reaction most probably means an analogous biological expression of cellular injury and necrosis of the neoplastic cells.

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