纳洛酮对乙醇和乙醛致家兔脑电图改变的影响。

Substance and alcohol actions/misuse Pub Date : 1982-01-01
L Manzo, A Tartara, P Bo, M Maurelli, G Mazzella, F Savoldi
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引用次数: 0

摘要

给家兔单次静脉注射乙醇(0.6 g/kg)后,脑电图快速同步,行为发生改变,这种改变被阿片类拮抗剂纳洛酮(40微克/kg)逆转,并在一定程度上被阻止。脑室内连续输注乙醛,10或120微克/分钟。引起双相变化,脑电图激活和严重心动过缓,随后在输注后出现明显的同步。本研究的结果进一步证明纳洛酮能够抵消乙醇的一些急性作用。此外,他们不支持乙醛本身作为与轻度酒精中毒相关的脑电图变化的介质的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effects of naloxone on ethanol and acetaldehyde-induced electroencephalographic changes in rabbits.

Rabbits treated with a single IV dose of ethanol, 0.6 g/kg, exhibited rapid EEG synchronization and behavioral changes that were reversed and, in part, prevented by the opiate antagonist, naloxone, 40 micrograms/kg. The continuous intracerebroventricular infusion of acetaldehyde, 10 or 120 micrograms/min. caused biphasic changes with EEG activation and severe bradycardia followed by overt synchrony during the post-infusion period. The results of the present study provide further evidence for the ability of naloxone to counteract some acute effects of ethanol. Moreover, they do not support a role of acetaldehyde itself as mediator of EEG changes associated with mild alcohol intoxication.

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