大鼠松果体对长期服用去甲睾酮(一种纯孕激素避孕药)的细胞生理反应。

Endokrinologie Pub Date : 1982-11-01

B R Maiti, S Chakraborty

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引用次数: 0

摘要

慢性给予去甲睾酮75天引起循环白化大鼠松果体活性的明显抑制。除了细胞核直径减小外，细胞大小也可能减小。然而，黄体酮未能在该腺体中诱导有丝分裂。提示长期服用去甲睾酮对成年雌性白化大鼠松果体功能有不良影响。

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Cytophysiological response of the pineal gland to long-term administration of norethisterone (a progestogen-only contraceptive) in rats.

Chronic administration of norethisterone for 75 days caused a marked inhibition of the pineal gland activity of cycling albino rats. In addition to a decrease in the nuclear diameter, possibly the cell size also decreased. The progestin, however, failed to induce mitosis in this gland. It is suggested that prolonged administration of norethisterone exerts untoward effects on the pineal gland function in adult female albino rats.

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Endokrinologie

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