大鼠可移植急性髓性白血病的生长模式

Paolo Foa
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引用次数: 0

摘要

通过静脉注射绿白血病细胞诱导近交系Sprague-Dawley大鼠发生广泛性急性髓系白血病。在骨髓中,移植后不久就观察到胚细胞的定植,在疾病末期,白血病细胞约占整个细胞群的70%。在外周血中,红细胞和血小板计数在疾病晚期下降,而从第5天开始,由于胚细胞释放到血液中,白细胞计数逐渐增加。脾、肝、中枢神经系统也受累。移植动物的存活时间与注射细胞的数量相关:2 × 107个绿白血病细胞移植后存活时间为8.3天,接种量每减少10倍,存活时间增加约2.5天。结果表明,谢氏绿白血病模拟了人类急性髓系白血病的一些特征,具有可预测和高度可重复性的生长速率,从而为进一步提供了有用的实验模型。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Growth pattern of a transplantable acute myeloid leukemia in the rat

A generalized acute myeloid leukemia was induced in inbred Sprague-Dawley rats by intravenous injection of chloroleukemia cells. In the bone marrow, colonization by blast cells was observed soon after transplantation and at the end of the disease leukemia cells accounted for about 70% of the whole cell population. In the peripheral blood, erythrocyte and platelet counts decreased late in the disease, while from day 5 onwards there was a progressive increase in the leukocyte count owing to blast cells released into the bloodstream. Spleen, liver and central nervous system were also involved in the disease. The survival time of transplanted animals correlated with the number of cells injected: after transplantation of 2 × 107 chloroleukemia cells survival time was 8.3 days, and with each 10-fold reduction of the inoculum survival time increased by about 2.5 days. The data presented show that Shay chloroleukemia mimics some features of human acute myeloid leukemia and possesses a predictable and highly reproducible growth rate, thus providing a further useful experimental model.

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