慢性酒精给药后色氨酸吡咯酶的活化。

Substance and alcohol actions/misuse Pub Date : 1982-01-01
L Branchey, C S Lieber
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引用次数: 0

摘要

我们最近发现,酗酒者以及长期饮酒的狒狒和大鼠的血浆色氨酸水平下降。在本研究中,我们研究了色氨酸吡咯酶的变化,这被认为是色氨酸分解代谢的限速。长期饮酒的大鼠在摄入色氨酸后肝脏酶活性增加,犬尿氨酸生成增加。结论是,这种增强的酶活性可能是负责的,至少部分,我们观察到的血浆色氨酸水平下降。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Activation of tryptophan pyrrolase after chronic alcohol administration.

We have recently found decreased plasma tryptophan levels in alcoholics as well as in baboons and rats fed alcohol chronically. In the present study we investigated changes in tryptophan pyrrolase which is considered to be rate limiting for tryptophan catabolism. Rats fed alcohol chronically showed an increased activity of the enzyme in the liver and an increased formation of kynurenine after administration of a tryptophan load. It is concluded that this enhanced enzymatic activity may be responsible, at least in part, for the depressed plasma tryptophan levels we observed.

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