大鼠肝癌与小鼠畸胎瘤体细胞杂交体的蛋白质合成。

Somatic Cell Genetics Pub Date : 1983-01-01 DOI:10.1007/BF01544052

L K Wray, H K Jaeckle

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引用次数: 3

摘要

用二维(O'Farrell)电泳检测了大鼠肝癌(MHC)和小鼠畸胎瘤(PCC4AZAl)细胞及MHC与PCC4AZAl体细胞杂交体细胞胞内蛋白和分泌蛋白的合成。PCC4AZAl和杂交细胞的凝胶几乎相同，与MHC细胞的凝胶有很大不同。因此，畸胎癌表型在畸胎癌X型肝癌体细胞杂交中占主导地位。

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Protein synthesis by rat hepatoma x mouse teratocarcinoma somatic cell hybrids.

The synthesis of intracellular and secretory proteins by rat hepatoma (MHC) and mouse teratocarcinoma (PCC4AZAl) cells and MHC X PCC4AZAl somatic cell hybrids was examined with two-dimensional (O'Farrell) electrophoresis. The gels of the PCC4AZAl and hybrid cells were nearly identical and were quite different from those of the MHC cells. The teratocarcinoma phenotype was, therefore, dominant in the teratocarcinoma X hepatoma somatic cell hybrids.

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Somatic Cell Genetics

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